Abstract
The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.
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Winstanley, J., Cooke, T., Murray, G. et al. The long term prognostic significance of c-erbB-2 in primary breast cancer. Br J Cancer 63, 447–450 (1991). https://doi.org/10.1038/bjc.1991.103
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DOI: https://doi.org/10.1038/bjc.1991.103
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