Abstract
Cyclin D1 is a cell cycle regulator essential for G1 phase progression and is frequently overexpressed in several human tumour types as a consequence of gene amplification or chromosomal rearrangements. We analysed the expression of cyclin D1 in 75 patients with transitional cell carcinoma (TCC) to investigate the possible relationship between its expression and clinical outcome as well as histopathological findings using the immunohistochemical method. We observed strong staining (++, > 50% positive cells) for cyclin D1 in 19 cases (25.3%) and weak staining (+, 5-50% positive cells) in 19 cases (25.3%). Overexpression of cyclin D1 was not associated with tumour invasion. No significant association was found between overexpression of cyclin D1 and tumour grade (P > 0.05). We assessed the differences of disease-free interval in superficial tumours and actuarial survival probability in invasive tumours according to the status of cyclin D1 expression. Tumours with (++) staining for cyclin D1 recurred much more rapidly than (-) and/or (+) staining tumours (P < 0.01 for - vs ++; P < 0.05 for + vs ++). However, overexpression of cyclin D1 was not associated with a shortened overall survival of patients with invasive tumours (P < 0.1). These results suggest that genetic alteration of cyclin D1 appears to be an early event in the tumorigenesis of bladder TCC and is associated with early recurrence in superficial tumours.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shin, K., Kong, G., Kim, W. et al. Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers. Br J Cancer 75, 1788–1792 (1997). https://doi.org/10.1038/bjc.1997.305
Issue Date:
DOI: https://doi.org/10.1038/bjc.1997.305
This article is cited by
-
Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions
BMC Research Notes (2020)
-
Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways
Journal of Experimental & Clinical Cancer Research (2015)
-
Dysregulation of the Rb pathway in recurrent pleomorphic adenoma of the salivary glands
Virchows Archiv (2015)
-
The impact of cyclin D1 overexpression on the prognosis of bladder cancer: a meta-analysis
World Journal of Surgical Oncology (2014)
-
The CCND1 G870A polymorphism and susceptibility to bladder cancer
Tumor Biology (2014)