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  • Clinical Oncology
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Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma

British Journal of Cancer volume 77, pages 1492–1494 (1998)Cite this article

Abstract

Overexpression of transforming growth factor-beta isoforms (TGF-beta1, -beta2, -beta3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients. Significantly elevated levels of TGF-beta1 (4.2 x the controls, P = 0.0094) and of TGF-beta2 (1.5 x the controls, P = 0.012) but not of TGF-beta3 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-beta family in end-stage melanoma patients.

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Authors and Affiliations

  1. Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany

    K Krasagakis

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  1. K Krasagakis
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  2. D Thölke
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  3. B Farthmann
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  4. J Eberle
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  5. U Mansmann
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  6. CE Orfanos
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Krasagakis, K., Thölke, D., Farthmann, B. et al. Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma. Br J Cancer 77, 1492–1494 (1998). https://doi.org/10.1038/bjc.1998.245

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  • DOI: https://doi.org/10.1038/bjc.1998.245

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