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Retrospective comparison of allogeneic vs autologous transplantation for diffuse large B-cell lymphoma with early relapse or primary induction failure

Bone Marrow Transplantation volume 50, pages 134–136 (2015)Cite this article

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Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL), comprising approximately one-third of all cases of NHL.1 Although the addition of rituximab to conventional chemotherapy has improved the outcomes for patients with DLBCL, a significant number still relapse and eventually die from lymphoma.2 For patients with chemosensitive relapsed DLBCL autologous stem cell transplantation (auto-SCT) provides better outcomes than chemotherapy alone, with ~50% of patients able to achieve long-term disease-free survival.3,4

However, the outcomes are worse for patients with chemoresistant or high-risk disease. This includes patients with early relapse, defined as relapse less than 1 year after the date of diagnosis, primary induction failure (PIF), defined as less than complete response to first-line chemotherapy, and/or relapse after rituximab.

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Author notes

  1. A Ghobadi and E Nolley: These authors contributed equally to this work.

Authors and Affiliations

  1. Division of Medical Oncology, Washington University School of Medicine, St Louis, MO, USA

    A Ghobadi, A McBride, K Stockerl-Goldstein & A Cashen

  2. Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA

    E Nolley

  3. Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA

    J Liu

Authors
  1. A Ghobadi
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  2. E Nolley
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  3. J Liu
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  4. A McBride
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  5. K Stockerl-Goldstein
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  6. A Cashen
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Corresponding author

Correspondence to A Ghobadi.

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The authors declare no conflict of interest.

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Ghobadi, A., Nolley, E., Liu, J. et al. Retrospective comparison of allogeneic vs autologous transplantation for diffuse large B-cell lymphoma with early relapse or primary induction failure. Bone Marrow Transplant 50, 134–136 (2015). https://doi.org/10.1038/bmt.2014.198

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  • DOI: https://doi.org/10.1038/bmt.2014.198

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