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Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Cellular & Molecular Immunology volume 12, pages 466–473 (2015)Cite this article

Abstract

Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction (MI). We studied the immunological characteristics and clinical impact of CD8+CD57+ T cells in acute MI patients. The frequency of CD57+ cells among CD8+ T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57+ cells in the CD8+ T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8+CD57+ T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8+CD57+ T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8+CD57+ T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8+ T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8+ T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.

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Acknowledgements

This work was supported by the KAIST Future Systems Healthcare Project from the Ministry of Science, ICT & Future Planning of Korea and by the project of Global PhD Fellowship begun by the National Research Foundation of Korea in 2011. This study was also supported by the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).

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Author notes

  1. Hee Tae Yu and Jong-Chan Youn: The first two authors contributed equally to this article.

  2. Dr EC Shin, Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea. E-mail: ecshin@kaist.ac.kr

  3. Dr JW Ha, Cardiology Division, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea. E-mail: jwha@yuhs.ac

Authors and Affiliations

  1. Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea

    Hee Tae Yu, Jong-Chan Youn, Jino Lee, Seunghyun Park, Ho-Seok Chi & Eui-Cheol Shin

  2. Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Jong-Chan Youn, Sungha Park, Donghoon Choi & Jong-Won Ha

  3. Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea

    Jungsul Lee & Chulhee Choi

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Tae Yu, H., Youn, JC., Lee, J. et al. Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction. Cell Mol Immunol 12, 466–473 (2015). https://doi.org/10.1038/cmi.2014.74

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