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Long-term changes in gut hormones, appetite and food intake 1 year after subtotal gastrectomy with normal body weight

European Journal of Clinical Nutrition volume 64, pages 826–831 (2010)Cite this article

Subjects

Abstract

Background/Objectives:

No prospective study on the long-term effects of gastric resection on gastrointestinal hormonal changes in patients with normal body weight has been reported. The aim of this study was to evaluate the 1-year effect of subtotal gastrectomy on ghrelin and peptide YY (PYY)3−36 levels.

Subjects/Methods:

Eighteen patients with early gastric cancer underwent subtotal gastrectomy with Billroth I reconstruction. We assessed appetite, food intake, body composition, and ghrelin and PYY3–36 levels preoperatively and 1 year after surgery.

Results:

There were no significant difference in the preoperative daily food intake and 1 year after subtotal gastrectomy. Weight loss occurred in all study subjects; 11.7% (n=2), 55.5% (n=10) and 33.3% (n=6) of the patients lost <5%, 5–10% and >10% of their preoperative body weight, respectively. Body mass index, waist circumference and body fat significantly decreased 1 year after subtotal gastrectomy. There were no significant differences in the appetite visual analogue scale preoperatively and 1 year after subtotal gastrectomy. The plasma ghrelin concentration decreased significantly (P=0.006), whereas PYY3−36 did not show a significant change 1 year after subtotal gastrectomy.

Conclusions:

Ghrelin levels and body fat decreased significantly, whereas PYY3−36 levels as well as appetite and food intake did not change significantly 1 year after subtotal gastrectomy with normal body weight. These findings suggest that decreased ghrelin might contribute directly to reduced body fat.

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Acknowledgements

This work was supported by a Medical Research Institute Grant (2005-01) from Pusan National University, Busan, Korea.

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Authors and Affiliations

  1. Department of Surgery, Pusan National University Hospital, Busan, South Korea

    T Y Jeon

  2. Family Medicine Clinic, Pusan National University Yangsan Hospital, Yangsan, South Korea

    S Lee & D W Jeong

  3. Medical Education Unit, Pusan National University School of Medicine, Yangsan, South Korea

    S Lee

  4. Medical Research Institute, Pusan National University School of Medicine, Yangsan, South Korea

    S Lee

  5. Department of Laboratory Medicine, Pusan National University Hospital, Busan, South Korea

    H H Kim

  6. Department of Family Medicine, Pusan National University Hospital, Busan, South Korea

    Y J Kim, J G Lee & Y J Kim

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  1. T Y Jeon
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Correspondence to S Lee.

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Jeon, T., Lee, S., Kim, H. et al. Long-term changes in gut hormones, appetite and food intake 1 year after subtotal gastrectomy with normal body weight. Eur J Clin Nutr 64, 826–831 (2010). https://doi.org/10.1038/ejcn.2010.83

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  • DOI: https://doi.org/10.1038/ejcn.2010.83

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