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Clinical nutrition, enteral and parenteral nutrition

Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up

European Journal of Clinical Nutrition volume 66, pages 891–899 (2012)Cite this article

Subjects

Abstract

BACKGROUND/OBJECTIVES:

This study examined the effect of weight loss after 3, 6 and 12 months of Roux-en-Y Gastric Bypass (RYGB) on energy intake and on several biomarkers of oxidative stress such as levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and activity of catalase (CAT).

SUBJECTS/METHODS:

Study with a control group (CG), assessed once, and a bariatric group (BG) assessed at the basal period as well as at 3, 6 and 12 months post-surgery; both groups were composed of 5 men and 31 women (n=36). Age was 38.7±9.4 and 39.6±9.2 years old and body mass index (BMI) was 22.2±2.1 and 47.6±9.1 kg/m2, respectively. The variance measure quoted was SEM.

RESULTS:

The body weight at 12 months was 35.8±1.0% (P<0.001) lower than that of the basal period. At the basal period BG showed higher levels of NOx (P=0.007) and TBARS (P<0.001) and lower levels of vitamins C and E (P<0.001) compared with CG. After 3 months the activity of MPO was decreased (P<0.001). Six months after surgery GSH levels were decreased (P=0.037), whereas CAT activity was increased (P=0.029). After 12 months levels of NOx (P=0.004), TBARS (P<0.001), beta-carotene (P<0.001) and vitamin E (P<0.001) were decreased, whereas those of vitamin C (P<0.001) were increased compared with controls.

CONCLUSION:

RYGB followed by a daily vitamin supplement apparently attenuated pro-inflammatory and oxidative stress markers 1 year after surgery, but additional antioxidant supplementation appears necessary.

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Acknowledgements

We are grateful to the following for financial support: Fundação de Apoio à Pesquisa Científica e Tecnológica do Estado de Santa Catarina (FAPESC): Grant #14191/2007–7, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)–Bolsa Produtividade and Programa Institucional de Bolsa de Iniciação Científica (PIBIC), Programa de Pós-Graduação em Nutrição da Universidade Federal de Santa Catarina, Programa de Fomento à Pós-Graduação (PROF)/Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

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Authors and Affiliations

  1. Post-Graduate Programme in Nutrition, Federal University of Santa Catarina, Santa Catarina, Brazil

    V R G da Silva

  2. Department of Nutrition, Post-Graduate Programme in Nutrition, Federal University of Santa Catarina, Santa Catarina, Brazil

    E A M Moreira

  3. Department of Ecology and Zoology, Federal University of Santa Catarina, Santa Catarina, Brazil

    D Wilhelm-Filho

  4. Department of Nutrition, Federal University of Santa Catarina, Santa Catarina, Brazil

    J X de Miranda

  5. Post-Graduate Programme in Pharmacy, Federal University of Santa Catarina, Santa Catarina, Brazil

    J P Benincá & S V G Vigil

  6. Department of Pharmacy, Federal University of Santa Catarina, Santa Catarina, Brazil

    A M B Moratelli & T R Garlet

  7. Department of Clinical Medicine, Ribeirão Preto Medical College, University of São Paulo, Ribeirão Preto, Brazil

    M S de Souza Meirelles & H Vannucchi

  8. Department of Clinical Analysis, Federal University of Santa Catarina, Santa Catarina, Brazil

    T S Fröde

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Additional information

Contributors: EAMM had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: EAMM. Acquisition of data: VRGS, JXM. Analysis and interpretation of data: VRGS, JB, SVGV, AMBM, TRG, MSSM, HV, EAMM, DWF. Drafting of the manuscript: VRGS, EAMM, DWF. Critical revision of the manuscript for important intellectual content: EAMM, DWF, TSF. Statistical analysis: VRGS, EAMM. Final approval of the version to be submitted: EAMM, DWF. Obtained funding: EAMM, DWF, TSF.

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da Silva, V., Moreira, E., Wilhelm-Filho, D. et al. Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up. Eur J Clin Nutr 66, 891–899 (2012). https://doi.org/10.1038/ejcn.2012.17

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