Abstract
The scotopic threshold response (STR) is a recently discovered component of the electroretinogram. It is a corneal negative deflection elicited in the fully dark adapted eye to dim stimuli, and appears to originate in the inner retina. The STR was recorded in a group of 50 insulin dependent diabetics with various degrees of diabetic retinopathy, who had not undergone laser photocoagulation. In addition, the scotopic b-wave, oscillatory potentials (OPs) and a pattern electroretinogram (PERG) were recorded. Retinopathy was assessed with stereo colour photographs of the seven standard fields as defined in the Diabetic Retinopathy Study. Retinopathy level was assigned to each eye using a modification of the Airlie House Classification System. Fluorescein angiograms were taken using a 60° fundus camera and graded for the presence of leakage and capillary non-perfusion. There was a significant correlation between the severity of retinopathy and the amplitude and latency of the STR. There was a similar correlation with the amplitude and latency of the OPs, a weaker correlation with the amplitude of the PERG, but no significant correlation with the latency of the PERG. These results support an inner retinal origin for the STR and suggest a role for STR in the electroretinographic assessment of diabetic retinopathy.
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References
Gjotterberg M : The electroretinogram in diabetic retinopathy: A clinical study and critical survey. Acta Ophthalmol 1974, 52: 521–33.
Yonemura D and Kawasaki K : New approaches to ophthalmic electrodiagnosis by retinal oscillatory potentials, drug-induced responses from retinal pigment epithelium and cone potential. Doc Ophthalmol 1979, 48: 163–222.
Simonsen SE : Prognostic value of ERG (oscillatory potential) in juvenile diabetics. Acta Ophthalmol 1975, 123 (suppl): 223–4.
Bresnick GH, Korth K, Groo A, Palta M : Electroretinographic oscillatory potentials predict progression of diabetic retinopathy: preliminary report. Arch Ophthalmol 1984, 102: 1307–11.
Arden GB, Hamilton AMP, Wilson-Holt J, Ryan S, Yudkin JS, Kurtz A : Pattern electroretinograms become abnormal when background diabetic retinopathy deteriorates to a preproliferative stage: possible use as a screening test. Br J Ophthalmol 1986, 70: 330–5.
Coupland SG : A comparison of oscillatory potential and pattern electroretinogram measures in diabetic retinopathy. Doc Ophthalmol 1987, 66: 207–18.
Speros P and Price J : Oscillatory potentials. History, techniques and potential use in the evaluation of disturbances of retinal circulation. Surv Ophthalmol 1981, 25: 237–51.
Arden GB, Vaegan, Hogg CR : Clinical and experimental evidence that the pattern electroretinogram (PERG) is generated in more proximal layers than the focal electroretinogram (FERG). Ann NY Acad Sci 1982, 388: 580–601.
Sieving PA, Frishman LJ, Steinberg RH . Scotopic threshold response of proximal retina in cat. J Neurophysiol 1986, 56: 1048–61.
Sieving PA and Nino C : Scotopic threshold response (STR) of the human electroretinogram. Invest Ophthalmol Vis Sci ARVO Abstracts 1987, 28: 401.
Aylward GW, Vaegan, Billson FA : The scotopic threshold response in man. Clin Vis Sci (in press).
Vaegan : An improved method of constructing pattern electroretinogram electrodes. Doc Ophthalmnol Proc Ser 1984, 14: 287–92.
Wyszecki G and Stiles WS : Colour Science. Concepts and methods. Quantitative data and formulas. New York. J. Wiley. 1967.
Naka KI and Rushton WAH : S-potentials from colour units in the retina of fish (Cyprinidae). J Physiol (Lon) 1966, 85: 536–55.
Aylward GW : A simple method of fitting the Naka-Rushton equation. Clin Vis Sci (in press).
Diabetic Retinography Study Research Group: Report 7. A modification of the Airlie House classification of diabetic retinopathy. Invest Ophthalmol Vis Sci 1981, 21: 210–26.
Klein R, Klein BEK, Magli YL, Brothers RJ, Meuer SM, Moss SE, Davis MD : An alternative method of grading diabetic retinopathy. Ophthalmology 1986, 93: 1183–7.
Bresnick GH and Palta M : Oscillatory potential amplitudes. Relation to severity of diabetic retinopathy. Arch Ophthalmol 1987, 105: 929–33.
King-Smith PE, Loffing DH, Jones R : Rod and cone ERGs and their oscillatory potentials. Invest Ophthalmol Vis Sci 1985, 27: 270–3.
Aylward GW, Vaegan, Billson FA : The wide-angle pattern electroretinogram. Doc Ophthalmol (in press).
Drasdo N, Thompson DA, Thompson CM, Edwards L : Complementary components and local variations of the pattern electroretinogram. Invest Ophthalmol Vis Sci 1987, 28: 158–62.
Johnson MA, Marcus S, Elman MJ, McPhee TJ : Neovascularisation in central retinal vein occlusion: Electroretinographic findings. Arch Ophthalmol 1988, 106: 348–52.
Flower RW and Patz A : The effect of hyperbaric oxygenation on retinal ischaemia. Invest Ophthalmol Vis Sci 1971, 10: 605–16.
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Aylward, G. The scotopic threshold response in diabetic retinopathy. Eye 3, 626–637 (1989). https://doi.org/10.1038/eye.1989.97
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DOI: https://doi.org/10.1038/eye.1989.97
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