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Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis

Genes & Immunity volume 10, pages 495–502 (2009)Cite this article

Abstract

The aim of this study was to perform a meta-analysis of the association between the factor V Leiden polymorphism (FVL) and thrombosis among patients with systemic lupus erythematosus (SLE) and/or antiphospholipid antibody (aPL) positivity. Included studies recruited patients based on SLE or aPL-positive status, confirmed subjects’ SLE diagnosis as defined by the American College of Rheumatology, and documented thrombotic events. Excluded studies were non-English or considered only arterial thrombosis. Individual patient data, available from 5 studies, together with unpublished data from 1210 European-American SLE patients from the UCSF Lupus Genetics Collection genotyped for FVL, were further analyzed. Seventeen studies (n=2090 subjects) were included in the initial meta-analysis. Unadjusted odds ratios (OR) were calculated to assess association of FVL with thrombosis. The OR for association of thrombosis with FVL was 2.88 (95% confidence interval (CI) 1.98–4.20). In the secondary analysis with our individual patient dataset (n=1447 European-derived individuals), SLE subjects with the FVL polymorphism still had more than two times the odds of thrombosis compared to subjects without this polymorphism, even when adjusting for covariates such as gender, age and aPL status. SLE and/or aPL-positive patients with the FVL variant have more than two times the odds of thrombosis compared to those without this polymorphism.

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Acknowledgements

We thank the following authors who contributed individual-level patient data: Paul R Fortin MD MPH, Paul Ames MD, Tom Ortel MD PhD and Ronit Simantov MD. This work was supported in part by an Arthritis Foundation Post-Doctoral Fellowship Award, an Alliance for Lupus Research Grant, a Kirkland Scholar Award, and NIH grants R01 AR22804, K24 AR02175 and P60 AR0533008. This study was performed in part in the General Clinical Research Center, Moffitt Hospital, University of California, San Francisco, with funds provided by the National Center for Research Resources, 5 M01 RR-00079, US Public Health Service.

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  1. A B Begovich

    Present address: 3Current address: Roche Diagnostics, Pleasanton, CA, USA.,

Authors and Affiliations

  1. Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco (UCSF), San Francisco, CA, USA

    R Kaiser, J L Barton & L A Criswell

  2. Discovery Research, Celera, Alameda, CA, USA

    M Chang, J J Catanese, Y Li & A B Begovich

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  1. R Kaiser
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  7. L A Criswell
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Correspondence to L A Criswell.

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Kaiser, R., Barton, J., Chang, M. et al. Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. Genes Immun 10, 495–502 (2009). https://doi.org/10.1038/gene.2009.32

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