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Is there a concordance between carotid and penile cavernosal artery intima-media thickness in patients with erectile dysfunction?

International Journal of Impotence Research volume 24, pages 44–48 (2012)Cite this article

Abstract

This study aimed to investigate the predictive accuracy of carotid and cavernosal Doppler ultrasound findings for discriminating patients with vasculogenic erectile dysfunction (ED). Fifty patients with complaints of ED were included. B-mode ultrasound of bilateral carotid arteries were performed and peak systolic velocity (PSV), end-diastolic velocity (EDV) and intima-media thickness (IMT) values were measured. Afterwards, corresponding values of cavernosal arteries were obtained by penile color duplex ultrasonography (P-CDU). Of total 50 patients, 29 (58%) were included in vasculogenic ED group and 21 (42%) in non-vasculogenic ED group according to P-CDU findings. There was a significant difference between groups for cavernosal IMT (P=0.012) but not for carotid IMT (P=0.601). When patients were reclassified according to carotid IMT values (IMT of the first group <0.9 mm and the second ⩾0.9 mm), carotid PSV and EDV values were different (P=0.033 and 0.018, respectively). Cavernosal PSV and EDV displayed no difference (P=0.816 and 0.123) while cavernosal IMT and percent change of cavernosal caliper were significantly different (P=0.014 and 0.018). Carotid PSV and EDV successfully mirrored respective measurements in cavernosal artery. However, carotid IMT failed to demonstrate such a correlation. Cavernosal IMT seems promising as an additional tool in the evaluation of cavernosal function.

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References

  1. Drexler H, Hornig B . Endothelial dysfunction in human disease. J Mol Cell Cardiol 1999; 31: 51–60.

    Article  CAS  Google Scholar 

  2. Solomon H, Man JW, Jackson G . Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251–253.

    Article  CAS  Google Scholar 

  3. Montorsi P, Montorsi F, Schulman CC . Is erectile dysfunction the ‘tip of the iceberg’ of a systemic vascular disorder? Eur Urol 2003; 44: 352–354.

    Google Scholar 

  4. Kirby M, Jackson G, Simonsen U . Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract 2005; 59: 225–229.

    Article  CAS  Google Scholar 

  5. Guay AT . Relation of endothelial cell function to erectile dysfunction: implications for treatment. Am J Cardiol 2005; 96: 52–56.

    Article  Google Scholar 

  6. Maxwell AJ . Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases. Nitric Oxide 2002; 6: 101–124.

    Article  CAS  Google Scholar 

  7. Endemann DH, Schiffrin EL . Endothelial dysfunction. J Am Soc Nephrol 2004; 15: 1983–1992.

    Article  CAS  Google Scholar 

  8. Costa C, Virag R . The endothelial-erectile dysfunction connection: an essential update. J Sex Med 2009; 6: 2390–2404.

    Article  CAS  Google Scholar 

  9. Kaiser DR, Billups K, Mason C, Wetterling R, Lundberg JL, Bank AJ . Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 2004; 43: 179–184.

    Article  Google Scholar 

  10. Guay AT . ED2: erectile dysfunction = endothelial dysfunction. Endocrinol Metab Clin N Am 2007; 36: 453–463.

    Article  Google Scholar 

  11. Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C . Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 1991; 134: 250–256.

    Article  CAS  Google Scholar 

  12. Kuller L, Borhani N, Furberg C, Gardin J, Manolio T, O'Leary D et al. Prevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the Cardiovascular Health Study. Am J Epidemiol 1994; 139: 1164–1179.

    Article  CAS  Google Scholar 

  13. Chambless LE, Folsom AR, Davis V, Sharrett R, Heiss G, Sorlie P et al. Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987–1998. Am J Epidemiol 2002; 155: 38–47.

    Article  Google Scholar 

  14. Furberg CD, Byington RP, Borhani NA . Multicenter isradipine diuretic atherosclerosis study (MIDAS). Design features. The Midas Research Group. Am J Med 1989; 86: 37–39.

    Article  CAS  Google Scholar 

  15. Bots ML, Hofman A, Grobbee DE . Common carotid intima-media thickness and lower extremity arterial atherosclerosis. The Rotterdam Study. Arterioscler Thromb 1994; 14: 1885–1891.

    Article  CAS  Google Scholar 

  16. Caretta N, Palego P, Schipilliti M, Ferlin A, Di Mambro A, Foresta C . Cavernous artery intima-media thickness: a new parameter in the diagnosis of vascular erectile dysfunction. J Sex Med 2009; 6: 1117–1126.

    Article  Google Scholar 

  17. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486–2497.

    Article  Google Scholar 

  18. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N et al. Mannheim carotid intima-media thickness consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 2007; 23: 75–80.

    Article  Google Scholar 

  19. Lue TF, Hricak H, Marich KW, Tanagho EA . Vasculogenic impotence evaluated by high-resolution ultrasonography and pulsed Doppler spectrum analysis. Radiology 1985; 155: 777–781.

    Article  CAS  Google Scholar 

  20. Shamloul R . Peak systolic velocities may be falsely low in young patients with erectile dysfunction. J Sex Med 2006; 3: 138–143.

    Article  Google Scholar 

  21. Speel TG, van Langen H, Wijkstra H, Meuleman EJ . Penile duplex pharmaco-ultrasonography revisited: revalidation of the parameters of the cavernous arterial response. J Urol 2003; 169: 216–220.

    Article  CAS  Google Scholar 

  22. Meuleman EJ, Bemelmans BL, van Asten WN, Doesburg WH, Skotnicki SH, Debruyne FM . Assessment of penile blood flow by duplex ultrasonography in 44 men with normal erectile potency in different phases of erection. J Urol 1992; 147: 51–56.

    Article  CAS  Google Scholar 

  23. Bocchio M, Scarpelli P, Necozione S, Pelliccione F, Mhialca R, Spartera C et al. Intima-media thickening of common carotid arteries is a risk factor for severe erectile dysfunction in men with vascular risk factors but no clinical evidence of atherosclerosis. J Urol 2005; 173: 526–529.

    Article  Google Scholar 

  24. Salonen JT, Salonen R . Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb 1991; 11: 1245–1249.

    Article  CAS  Google Scholar 

  25. Ucar G, Secil M, Demir O, Demir T, Comlekci A, Uysal S et al. The combined use of brachial artery flow-mediated dilatation and carotid artery intima-media thickness measurements may be a method to determine vasculogenic erectile dysfunction. Int J Impot Res 2007; 19: 577–583.

    Article  CAS  Google Scholar 

  26. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Briganti A, Salonia A et al. The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005; 96 (12B): 19M–23M.

    Article  Google Scholar 

  27. Foresta C, Palego P, Schipilliti M, Selice R, Ferlin A, Caretta N . Asymmetric development of peripheral atherosclerosis in patients with erectile dysfunction: an ultrasonographic study. Atherosclerosis 2008; 197: 889–895.

    Article  CAS  Google Scholar 

  28. Bocchio M, Scarpelli P, Necozione S, Pelliccione F, Spartera C, Francavilla F et al. Penile duplex pharmaco-ultrasonography of cavernous arteries in men with erectile dysfunction and generalized atherosclerosis. Int J Androl 2006; 29: 496–501.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Numune Education and Research Hospital, Ankara, Turkey

    C S Gokkaya, B K Aktas, S Yahsi, S Bulut, C Ozden & A Memis

  2. Department of Radiology, Numune Education and Research Hospital, Ankara, Turkey

    U Toprak

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  1. C S Gokkaya
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  2. B K Aktas
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  4. S Yahsi
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Correspondence to B K Aktas.

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Gokkaya, C., Aktas, B., Toprak, U. et al. Is there a concordance between carotid and penile cavernosal artery intima-media thickness in patients with erectile dysfunction?. Int J Impot Res 24, 44–48 (2012). https://doi.org/10.1038/ijir.2011.46

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  • DOI: https://doi.org/10.1038/ijir.2011.46

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