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Echocardiographic predictors of symptomatic patent ductus arteriosus in extremely-low-birth-weight preterm neonates

Journal of Perinatology volume 30, pages 535–539 (2010)Cite this article

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Abstract

Objective:

Identify echocardiographic parameters at ⩽4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW).

Study Design:

Serial echocardiograms obtained in 115 ELBW at ⩽10 day postnatal were examined to estimate PDA size using the PDA:left pulmonary artery (LPA) diameter ratio: ⩾1 indicated a large PDA, <1 but ⩾0.5 moderate, and <0.5 small. Sensitivity, specificity, and positive predictive values (PPV) were determined for ELBW <27 weeks and ⩾27 weeks gestational age.

Result:

Neonates with moderate to large PDA at ⩽4 day had 15-times greater likelihood of requiring treatment for sPDA than those with a small PDA (95% confidence interval (CI): 5.6–41). Sensitivity, specificity and PPV of the PDA:LPA at <27 weeks was 80, 86 and 92%, respectively.

Conclusion:

A moderate to large PDA determined from the PDA:LPA ratio at ⩽4 day postnatal identifies neonates <27 week gestation who subsequently require closure of a PDA.

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Authors and Affiliations

  1. Division of Cardiology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA

    F G Ramos & C Ramaciotti

  2. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA

    C R Rosenfeld & J Koch

  3. Department of Planning, Children's Medical Center of Dallas, Dallas, TX, USA

    L Roy

Authors
  1. F G Ramos
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  2. C R Rosenfeld
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  3. L Roy
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  4. J Koch
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  5. C Ramaciotti
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Corresponding author

Correspondence to C R Rosenfeld.

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The authors declare no conflict of interest.

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Ramos, F., Rosenfeld, C., Roy, L. et al. Echocardiographic predictors of symptomatic patent ductus arteriosus in extremely-low-birth-weight preterm neonates. J Perinatol 30, 535–539 (2010). https://doi.org/10.1038/jp.2010.14

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  • DOI: https://doi.org/10.1038/jp.2010.14

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