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The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation

Journal of Perinatology volume 36, pages 474–480 (2016)Cite this article

Subjects

Abstract

Objective:

To determine risk factors for acute kidney injury (AKI) in preterm infants as a function of time of onset.

Study Design:

In this 5 1/2-year, single-center, retrospective study, incidence and timing of AKI was determined using modified Acute Kidney Injury Network criteria. Characteristics of newborns with and without AKI were compared by chi square and t-tests. Logistic regression was used to examine risk factors for AKI as a function of time of onset and potential confounders.

Result:

AKI occurred in 30.3% of 357 neonates; 72.2% was stage 1. Gestational ages (GA), initial Cr, maternal magnesium and volume resuscitation were associated with early AKI (days 0 to 1). Volume resuscitation, umbilical arterial line and receipt of non-steroidal anti-inflammatory drug (NSAID) for patent ductus arteriosus were associated with intermediate AKI (days 2 to 5). GA, steroids for early hypotension, necrotizing enterocolitis and sepsis were associated with late AKI (⩾day 6).

Conclusion:

Stage 1 AKI is a common morbidity in our population. Risk factors for AKI in our population differed with time of onset.

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Author information

Authors and Affiliations

  1. Division of Newborn Medicine, Department of Pediatrics, Kravis Children’s Hospital, Mount Sinai Medical Center, The Icahn School of Medicine at Mount Sinai, New York, NY, USA

    A S Weintraub, J Connors & R S Green

  2. The Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA

    A Carey

  3. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA

    V Blanco

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  1. A S Weintraub
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Correspondence to A S Weintraub.

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Weintraub, A., Connors, J., Carey, A. et al. The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation. J Perinatol 36, 474–480 (2016). https://doi.org/10.1038/jp.2015.217

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