This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Hairy cell leukemia: a specific 17-gene expression signature points to new targets for therapy
Journal of Cancer Research and Clinical Oncology Open Access 27 April 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al.Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organisation Classification of Tumours. IARC Press: Lyon, France, 2008.
Weill JC, Weller S, Reynaud CA . Human marginal zone B cells. Annu Rev Immunol 2009; 27: 267–285.
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T . Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102: 553–563.
Greeve J, Philipsen A, Krause K, Klapper W, Heidorn K, Castle BE et al. Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas. Blood 2003; 101: 3574–3580.
Oppezzo P, Dumas G, Lalanne AI, Payelle-Brogard B, Magnac C, Pritsch O et al. Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells. Blood 2005; 105: 2495–2503.
Hockley SL, Giannouli S, Morilla A, Wotherspoon A, Morgan GJ, Matutes E et al. Insight into the molecular pathogenesis of hairy cell leukaemia, hairy cell leukaemia variant and splenic marginal zone lymphoma, provided by the analysis of their IGH rearrangements and somatic hypermutation patterns. Br J Haematol 2010; 148: 666–669.
Matutes E, Morilla R, Owusu-Ankomah K, Houliham A, Meeus P, Catovsky D . The immunophenotype of hairy cell leukemia (HCL). Proposal for a scoring system to distinguish HCL from B-cell disorders with hairy or villous lymphocytes. Leuk Lymphoma 1994; 14: 57–61.
Matutes E, Wotherspoon A, Catovsky D . The variant form of hairy-cell leukaemia. Best Pract Res Clin Haematol 2003; 16: 41–56.
Forconi F, Sozzi E, Rossi D, Sahota SS, Amato T, Raspadori D et al. Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia. Haematologica 2008; 93: 697–705.
Basso K, Liso A, Tiacci E, Benedetti R, Pulsoni A, Foa R et al. Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors. J Exp Med 2004; 199: 59–68.
Traverse-Glehen A, Davi F, Ben Simon E, Callet-Bauchu E, Felman P, Baseggio L et al. Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection. Haematologica 2005; 90: 470–478.
Acknowledgements
We thank Dr Mark Catherwood for providing some of the FL controls used in this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Hockley, S., Morilla, A., Else, M. et al. Higher expression levels of activation-induced cytidine deaminase distinguish hairy cell leukemia from hairy cell leukemia-variant and splenic marginal zone lymphoma. Leukemia 24, 1084–1086 (2010). https://doi.org/10.1038/leu.2010.44
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2010.44
This article is cited by
-
Hairy cell leukemia: a specific 17-gene expression signature points to new targets for therapy
Journal of Cancer Research and Clinical Oncology (2022)
-
Grey zone lymphoid neoplasms with features overlapping between splenic marginal zone lymphoma and hairy cell leukaemia: splenic B-cell lymphoma/leukaemia, unclassifiable
Journal of Hematopathology (2011)