Although all cells within a colon cancer may harbour adenomatous polyposis coli (APC) or β-catenin mutations, activation of Wnt signalling is limited to a subpopulation of cells that display cancer stem cell properties. This activation requires a co-stimulatory signal mediated by hepatocyte growth factor, which is produced by tumour-associated myofibroblasts.
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M.S.Wicha is a scientific consultant for, and holds equity in, OncoMed Pharmaceuticals.
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Korkaya, H., Wicha, M. Cancer stem cells: nature versus nurture. Nat Cell Biol 12, 419–421 (2010). https://doi.org/10.1038/ncb0510-419
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DOI: https://doi.org/10.1038/ncb0510-419
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