Anti-tubulin drugs are life-saving chemotherapeutics that kill cancer cells by stabilizing or disrupting microtubules. Despite their clinical utility, the molecular mechanisms by which anti-tubulins cause apoptotic cell death remain poorly understood. It is now shown that microtubule disruption can inhibit anti-apoptotic Bcl-2 family proteins through an evolutionarily conserved signalling axis involving DEPDC1 (LET-99 in Caenorhabditis elegans) and JNK.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model
Scientific Reports Open Access 11 November 2020
-
Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues
Scientific Reports Open Access 21 December 2016
-
From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor
Cell Death & Disease Open Access 17 March 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jackson, J. R., Patrick, D. R., Dar, M. M. & Huang, P. S. Nat. Rev. Cancer 7, 107–117 (2007).
Jordan, M. A. & Wilson, L. Nat. Rev. Cancer 4, 253–265 (2004).
Rieder, C. L. & Maiato, H. Dev. Cell 7, 637–651 (2004).
Shi, J., Orth, J. D. & Mitchison, T. Cancer Res. 68, 3269–3276 (2008).
Wertz, I. E. et al. Nature 471, 110–114 (2011).
Youle, R. J. & Strasser, A. Nat. Rev. Mol. Cell Biol. 9, 47–59 (2008).
Inuzuka, H. et al. Nature 471, 104–109 (2011).
Sendoel, A. et al. Nat. Cell Biol. 16, 812–820 (2014).
Yuan, J. & Horvitz, H. R. Cell 116, S53–56 (2004).
Derry, W. B., Putzke, A. P. & Rothman, J. H. Science 294, 591–595 (2001).
Rose, L. S. & Kemphues, K. Development 125, 1337–1346 (1998).
Tsou, M-F. B., Hayashi, A., DeBella, L. R., McGrath, G. & Rose, L. S. Development 129, 4469–4481 (2002).
Consonni, S. V., Maurice, M. M. & Bos, J. L. Nat. Rev. Mol. Cell Biol. 15, 357–362 (2014).
Bringmann, H., Cowan, C. R., Kong, J. & Hyman, A. A. Curr. Biol. 17, 185–191 (2007).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Denning, D., Hirose, T. Anti-tubulins DEPendably induce apoptosis. Nat Cell Biol 16, 741–743 (2014). https://doi.org/10.1038/ncb3012
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3012
This article is cited by
-
Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model
Scientific Reports (2020)
-
From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor
Cell Death & Disease (2016)
-
Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues
Scientific Reports (2016)
