Human C-reactive protein (CRP) has been implicated in the inflammatory responses associated with heart attacks and strokes. A small-molecule inhibitor of CRP limits myocardial infarction in rats and should facilitate mechanistic studies of cardiovascular disease.
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Heinecke, J. Chemical knockout of C-reactive protein in cardiovascular disease. Nat Chem Biol 2, 300–301 (2006). https://doi.org/10.1038/nchembio0606-300
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DOI: https://doi.org/10.1038/nchembio0606-300
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