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Lack of Correlation between Interferon Induction and Antitumour Effect of Poly I · Poly C

Nature New Biology volume 231, pages 53–54 (1971)Cite this article

Abstract

POLYINOSINIC polycytidylic acid (poly I · poly C) is a potent inducer of interferon and produces resistance to viral infection in vivo and in vitro1–5. Its action in protecting animals and tissue culture preparations against the tumour inducing and focus forming properties of the Moloney strain of murine sarcoma virus (MSV–M) has been described6–9, and we have now investigated the effects of quantity of virus, strain of mouse and concentrations of induced interferon on the anti-MSV–M action of poly I · poly C.

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Authors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland

    ALLAN J. WEINSTEIN, ADI F. GAZDAR & HARVIE L. SIMS

  2. National Institute of Allergy and Infectious Disease, Bethesda, Maryland

    HILTON B. LEVY

Authors
  1. ALLAN J. WEINSTEIN
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  2. ADI F. GAZDAR
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  3. HARVIE L. SIMS
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  4. HILTON B. LEVY
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WEINSTEIN, A., GAZDAR, A., SIMS, H. et al. Lack of Correlation between Interferon Induction and Antitumour Effect of Poly I · Poly C. Nature New Biology 231, 53–54 (1971). https://doi.org/10.1038/newbio231053a0

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  • DOI: https://doi.org/10.1038/newbio231053a0

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