Abstract
WE have previously reported the oncolytic effect of bovine enterovirus 1 on Ehrlich carcinoma and sarcoma 1 in both the solid and ascites form in mice. The basis of the oncolytic specificity was associated with the adsorption spectrum of the virus1,2. We have now extended this work to a larger spectrum of transplantable tumours in inbred strains of mice, and to initial experiments on the cytopathic effect of BE virus on a number of cell lines and primary cells of human origin. These results demonstrate that the oncolytic effect of BE virus, and perhaps other enteroviruses, may be more than a “laboratory curiosity”3 and may be of use against certain types of neoplasia.
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Experimental immunization of mice with a recombinant bovine enterovirus vaccine expressing BVDV E0 protein elicits a long-lasting serologic response
Virology Journal Open Access 01 July 2020
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SEDMAK, G., TAYLOR, M., MEALEY, J. et al. Oncolytic Effect of Bovine Enterovirus on Mouse and Human Tumours. Nature New Biology 238, 7–9 (1972). https://doi.org/10.1038/newbio238007a0
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DOI: https://doi.org/10.1038/newbio238007a0
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