Theories of cancer biology have long held that the metastatic process originates with rare cells within the primary tumor. A new study using expression array analysis has identified a molecular signature of metastatic potential within the bulk of the primary tumor. This suggests that the majority of tumor cells have the potential to metastasize and presents exciting clinical and therapeutic applications.
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Liotta, L., Kohn, E. Cancer's deadly signature. Nat Genet 33, 10–11 (2003). https://doi.org/10.1038/ng0103-10
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DOI: https://doi.org/10.1038/ng0103-10
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