The direct inhibition of DNA mismatch repair by cadmium provides a molecular mechanism for cadmium toxicity with profound implications for human health, risk assessment and biological understanding of environmental mutagens. Alteration of key DNA damage response pathways may prove even more important than direct DNA damage by mutagens.
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McMurray, C., Tainer, J. Cancer, cadmium and genome integrity. Nat Genet 34, 239–241 (2003). https://doi.org/10.1038/ng0703-239
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DOI: https://doi.org/10.1038/ng0703-239
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