Regulatory B cells exert an immunosuppressive role by secreting the cytokine interleukin-10 (IL-10). Two studies have now identified B cell–derived IL-35 as both an inducer and a mediator of regulatory B cell function. IL-35 switched off inflammation in mouse models of autoimmunity, whereas its absence in B cells in mice enhanced survival after Salmonella enterica serovar Typhimurium infection. IL-35 could therefore be targeted for treating human autoimmune and infectious disease.
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Mauri, C., Nistala, K. Interleukin-35 takes the 'B' line. Nat Med 20, 580–581 (2014). https://doi.org/10.1038/nm.3594
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DOI: https://doi.org/10.1038/nm.3594
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