Persistence of Mycobacterium tuberculosis in humans depends on its ability to survive within the host macrophage. So the bacterium must resist antimicrobial mechanisms or subvert macrophage signaling pathways to prevent its death. Recent evidence suggests that the two strategies are not mutually exclusive.
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Warner, D., Mizrahi, V. The survival kit of Mycobacterium tuberculosis. Nat Med 13, 282–284 (2007). https://doi.org/10.1038/nm0307-282
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DOI: https://doi.org/10.1038/nm0307-282
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