Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NF-κB and bone: The breaking point

New findings suggest that NF-κB proteins regulate osteoclast differentiation and are potential therapeutic targets for treating osteoporosis (pages 1285—1289).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Baeuerle P.A. & Baltimore D. NF-κB: ten years after. Cell 87, 13–20 (1996).

    Article  CAS  Google Scholar 

  2. Lotsova V., Caamano J., Loy J., Lewin, A. & Bravo, R. Osteopetrosis in mice lacking NF-κB1 and NF-κB2. Nature Mad. 3, 1285–1289 (1997).

    Article  Google Scholar 

  3. Grigoriadis, A.E. et al. c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443–448 (1994).

    Article  CAS  Google Scholar 

  4. Manolagas, S.C., Bellido, T. & Jilka, R.L. New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: Roles of IL-6 and gp130. Int. J. Immunopharmacol. 17, 109–116 (1995).

    Article  CAS  Google Scholar 

  5. Pacifici R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J. Bone Miner. Res. 11, 1043–1051 (1996).

    Article  CAS  Google Scholar 

  6. Ray A., Prefontaine K.E. & Ray, P. Downregulation of interleukin-6 gene by 17 beta-estradiol in the absence of high affinity DMA binding by the estrogen receptor. J. Biol. Chem. 269, 12940–12946 (1994).

    CAS  PubMed  Google Scholar 

  7. Stein, B. & Yang, M.X. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol. Cell. Biol. 15, 4971–4979 (1995).

    Article  CAS  Google Scholar 

  8. Tondravi, M.M. et al. Osteopetrosis in mice lacking hematopoietic transcription factor PU.1. Nature 386, 81–84 (1997).

    Article  CAS  Google Scholar 

  9. Stein, B. et al. Cross-coupling of the NF-kappa B p65 and Fos-Jun transcription factors produces potentiated biological function. EMBO J. 12, 3879–3891 (1993).

    Article  CAS  Google Scholar 

  10. Bassuk A.G. & Leiden J.M. A direct physical association between ETS and AP-1 transcription factors in normal human T Cells. Immunity 3, 223–237 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abu-Amer, Y., Tondravi, M. NF-κB and bone: The breaking point. Nat Med 3, 1189–1190 (1997). https://doi.org/10.1038/nm1197-1189

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1197-1189

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing