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Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

Nature Medicine volume 1, pages 1257–1260 (1995)Cite this article

Abstract

The elucidation of molecular alterations that occur during human breast cancer progression may contribute to the development of preventative strategies. Using in situ hybridizations on a cohort of 94 biopsy lesions, quantitatively increased cyclin D mRNA expression levels were observed in only 18% of benign lesions, which confer no or slightly increased breast cancer risk, and 18% of premalignant atypical ductal hyperplasias, which confer a four to fivefold increase in breast cancer risk. The transition to carcinoma was accompanied by frequent cyclin D mRNA overexpression in 76% of low-grade ductal carcinomas in situ, 87% of higher grade comedo ductal carcinomas in situ and 83% of infiltrating ductal breast carcinomas. The data identify a molecular event that may separate benign and premalignant human breast lesions from any form of breast carcinoma.

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Authors and Affiliations

  1. Women's Cancers Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Building 10, Room 2A33, Bethesda, Maryland, 20892, USA

    Debra Weinstat-Saslow, Richard E. Manrow, Julia A. Lawrence & Patricia S. Steeg

  2. Surgical Pathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Building 10, Room 2N212, Bethesda, Maryland, 20892, USA

    Maria J. Merino

  3. Department of Pathology, Vanderbilt University School of Medicine, MCN, Room C-3311, Nashville, Tennessee, 37232, USA

    Ray F. Bluth, Karl D. Wittenbel & David L. Page

  4. Division of Pathology, City of Hope National Medical Center, 1500 E. Duarte Street, Duarte, California, 91010, USA

    Jean F. Simpson

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  1. Debra Weinstat-Saslow
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Weinstat-Saslow, D., Merino, M., Manrow, R. et al. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nat Med 1, 1257–1260 (1995). https://doi.org/10.1038/nm1295-1257

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