Abstract
We found that personality characteristics are linked to dissociable connectivity streams in the human brain. Whereas fiber tracts between a subcortical network, including the hippocampus and amygdala, and the ventral striatum predicted individual differences in novelty seeking, tracts between prefrontal cortex and the striatum predicted individual differences in reward dependence. These findings suggest that the strength of limbic-striatal connectivity may, in part, underlie human personality traits.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Everitt, B.J. & Robbins, T.W. Nat. Neurosci. 8, 1481–1489 (2005).
Haber, S.N., Kim, K.S., Mailly, P. & Calzavara, R. J. Neurosci. 26, 8368–8376 (2006).
Robbins, T.W., Cador, M., Taylor, J.R. & Everitt, B.J. Neurosci. Biobehav. Rev. 13, 155–162 (1989).
Lisman, J.E. & Grace, A.A. Neuron 46, 703–713 (2005).
Hollerman, J.R., Tremblay, L. & Schultz, W. Prog. Brain Res. 126, 193–215 (2000).
Cloninger, C.R., Svrakic, D.M. & Przybeck, T.R. Arch. Gen. Psychiatry 50, 975–990 (1993).
Behrens, T.E. et al. Nat. Neurosci. 6, 750–757 (2003).
Cohen, M.X., Lombardo, M. & Blumenfeld, R.S. Eur. J. Neurosci. 27, 1534–1546 (2008).
Draganski, B. et al. J. Neurosci. 28, 7143–7152 (2008).
Peters, J.R., Vallie, B., Difronzo, M. & Donaldson, S.T. Brain Res. Bull. 74, 232–236 (2007).
Bhatti, A.S., Hall, P., Ma, Z., Tao, R. & Isgor, C. Hippocampus 17, 922–933 (2007).
Sheth, A., Berretta, S., Lange, N. & Eichenbaum, H. Hippocampus 18, 169–181 (2008).
Rolls, E.T. Rev. Neurol. (Paris) 150, 648–660 (1994).
King–Casas, B. et al. Science 308, 78–83 (2005).
Cohen, M.X., Elger, C.E. & Weber, B. Neuroimage 39, 1396–1407 (2008).
Acknowledgements
We thank J.F. Cavanagh, M. Tittgemeyer and B. Knutson for helpful comments on the manuscript. J.S. and B.W. conducted the experiment, and M.X.C. analyzed the data and wrote the paper. All authors approved the analyses and manuscript.
Author information
Authors and Affiliations
Corresponding author
Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–6, Supplementary Tables 1 and 2, and Supplementary Methods (PDF 2873 kb)
Rights and permissions
About this article
Cite this article
Cohen, M., Schoene-Bake, JC., Elger, C. et al. Connectivity-based segregation of the human striatum predicts personality characteristics. Nat Neurosci 12, 32–34 (2009). https://doi.org/10.1038/nn.2228
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.2228