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Temsirolimus

Abstract

Temsirolimus (Torisel; Wyeth) is an inhibitor of the kinase mTOR (mammalian target of rapamycin). It was approved by the US FDA for the treatment of advanced renal cell carcinoma in May 2007.

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Figure 1: mTOR signalling and temsirolimus.

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B. R. has received research funding from Wyeth and is a paid consultant for Wyeth.

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Rini, B., Kar, S. & Kirkpatrick, P. Temsirolimus. Nat Rev Drug Discov 6, 599–600 (2007). https://doi.org/10.1038/nrd2382

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