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Bone

Elucidating which cell erythropoietin targets in bone

Nature Reviews Endocrinology volume 11, pages 263–264 (2015)Cite this article

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Identification of the cellular and molecular mechanisms that regulate bone remodelling is crucial for the development of effective skeletal therapeutics. A new study in mice shows that erythropoietin increases bone loss by enhancing osteoclast differentiation and bone resorption.

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References

  1. Hiram-Bab, S. et al. Erythropoietin directly stimulates osteoclast precursors and induces bone loss. FASEB J. http://dx.doi.org/10.1096/fj.14-259085.

  2. Broxmeyer, H. E. Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration. J. Exp. Med. 210, 205–208 (2013).

    Article  CAS  Google Scholar 

  3. McGee, S. J., Havens, A. M., Shiozawa, Y., Jung, Y. & Taichman, R. S. Effects of erythropoietin on the bone microenvironment. Growth Factors 30, 22–28 (2012).

    Article  CAS  Google Scholar 

  4. Shiozawa, Y. et al. Erythropoietin couples hematopoiesis with bone formation. PLoS ONE 5, e10853 (2010).

    Article  Google Scholar 

  5. Li, C. et al. Erythropoietin promotes bone formation through EphrinB2/EphB4 signaling. J. Dent. Res. http://dx.doi.org/10.1177/0022034514566431.

  6. Singbrant, S. et al. Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment. Blood 117, 5631–5642 (2011).

    Article  CAS  Google Scholar 

  7. Garcia, P. et al. Low dose erythropoietin stimulates bone healing in mice. J. Orthop. Res. 29, 165–172 (2011).

    Article  CAS  Google Scholar 

  8. Holstein, J. H. et al. Erythropoietin stimulates bone formation, cell proliferation, and angiogenesis in a femoral segmental defect model in mice. Bone 49, 1037–1045 (2011).

    Article  CAS  Google Scholar 

  9. Lee, M. Y., Fukunaga, R., Lee, T. J., Lottsfeldt, J. L. & Nagata, S. Bone modulation in sustained hematopoietic stimulation in mice. Blood 77, 2135–2141 (1991).

    CAS  PubMed  Google Scholar 

  10. Cho, S. W. et al. Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone. Proc. Natl Acad. Sci. USA 111, 1545–1550 (2014).

    Article  CAS  Google Scholar 

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Acknowledgements

Y.S. and R.S.T. thank Y. Jung and L. McCauley at the University of Michigan for helpful discussions and acknowledge research support from the NIH (grants DE020721, CA093900, CA163124 and CA143803).

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Authors and Affiliations

  1. Department of Cancer Biology and Comprehensive Cancer Centre, Wake Forest University School of Medicine, Medical Centre Boulevard, Winston-Salem, 27157, NC, USA

    Yusuke Shiozawa

  2. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, 48109, MI, USA

    Russell S. Taichman

Authors
  1. Yusuke Shiozawa
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  2. Russell S. Taichman
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Correspondence to Russell S. Taichman.

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The authors declare no competing financial interests.

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Shiozawa, Y., Taichman, R. Elucidating which cell erythropoietin targets in bone. Nat Rev Endocrinol 11, 263–264 (2015). https://doi.org/10.1038/nrendo.2015.32

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