Measurement of glomerular and peritubular capillaritis in kidney transplant biopsy samples identifies allograft dysfunction associated with alloantibodies. Sis et al. show that this technique has a higher sensitivity but lower specificity than the current diagnostic criteria using peritubular capillary C4d deposition, and that capillaritis is an independent predictor of progression to graft failure.
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Farkash, E., Colvin, R. Diagnostic challenges in chronic antibody-mediated rejection. Nat Rev Nephrol 8, 255–257 (2012). https://doi.org/10.1038/nrneph.2012.61
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DOI: https://doi.org/10.1038/nrneph.2012.61
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