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  • Year in Review
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Stroke in 2013

Disappointments and advances in acute stroke intervention

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Clinical trials in stroke intervention during the past year have yielded contrasting results. Endovascular therapies and procedures to reduce stroke risk caused by patent foramen ovale have failed to demonstrate superiority over standard medical treatments. By contrast, a trial of neuroprotection—traditionally thought to be ineffective in humans—offers hope.

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Figure 1: Evolution of the ischaemic core over time in cynomolgus macaques with AIS caused by middle cerebral artery occlusion.

References

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Correspondence to Michael Tymianski.

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Competing interests

M. Tymianski is president of NoNO Inc., a biotechnology company founded to develop PSD95 inhibitors discovered in his research laboratory.

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Tymianski, M. Disappointments and advances in acute stroke intervention. Nat Rev Neurol 10, 66–68 (2014). https://doi.org/10.1038/nrneurol.2013.271

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