Systems level analysis using stimulus–response modelling could increase our understanding of the interplay between biochemical, structural and functional variables that influence the development and manifestation of osteoarthritis. Furthermore, surrogate markers of clinical responses identified might enable early diagnosis, improve therapy, and facilitate development of new treatments and end points.
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Andriacchi, T. Probing knee OA as a system responding to a stimulus. Nat Rev Rheumatol 8, 371–372 (2012). https://doi.org/10.1038/nrrheum.2012.59
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DOI: https://doi.org/10.1038/nrrheum.2012.59
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