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Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC

Oncogene volume 27, pages 4592–4602 (2008)Cite this article

Abstract

The aim of this study is to investigate additional genetic alterations in papillary thyroid carcinomas (PTCs) with known RET/PTC rearrangements. We applied array-based comparative genomic hybridization (array CGH) to 33 PTC (20 PTC from adults, 13 post-Chernobyl PTC from children) with known RET/PTC status. Principal component analysis and hierarchical cluster analysis identified cases with similar aberration patterns. Significant deviations between tumour-groups were obtained by statistical testing (Fisher's exact test in combination with Benjamini–Hochberg FDR-controlling procedure). FISH analysis on FFPE sections was applied to validate the array CGH data. Deletions were found more frequently in RET/PTC-positive and RET/PTC-negative tumours than amplifications. Specific aberration signatures were identified that discriminated between RET/PTC-positive and RET/PTC-negative cases (aberrations on chromosomes 1p, 3q, 4p, 7p, 9p/q, 10q, 12q, 13q and 21q). In addition, childhood and adult RET/PTC-positive cases differ significantly for a deletion on the distal part of chromosome 1p. There are additional alterations in RET/PTC-positive tumours, which may act as modifiers of RET activation. In contrast, alterations in RET/PTC-negative tumours indicate alternative routes of tumour development. The data presented serve as a starting point for further studies on gene expression and function of genes identified in this study.

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Abbreviations

BAC:

bacterial artificial chromosome

CGH:

comparative genomic hybridization

FISH:

fluorescence in situ hybridization

PTC:

papillary thyroid carcinoma

References

  • Adolphe C, Hetherington R, Ellis T, Wainwright B . (2006). Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res 66: 2081–2088.

    Article  CAS  PubMed  Google Scholar 

  • Azuma K, Tanaka M, Uekita T, Inoue S, Yokota J, Ouchi Y et al. (2005). Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. Oncogene 24: 4754–4764.

    Article  CAS  PubMed  Google Scholar 

  • Camacho-Vanegas O, Narla G, Teixeira MS, DiFeo A, Misra A, Singh G et al. (2007). Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma. Int J Cancer 121: 1390–1395.

    Article  CAS  PubMed  Google Scholar 

  • Chang M, Bellaoui M, Zhang C, Desai R, Morozov P, Delgado-Cruzata L et al. (2005). RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J 24: 2024–2033.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cheung CC, Ezzat S, Ramyar L, Freeman JL, Asa SL . (2000). Molecular basis off hurthle cell papillary thyroid carcinoma. J Clin Endocrinol Metab 85: 878–882.

    CAS  PubMed  Google Scholar 

  • Chunduru S, Kawami H, Gullick R, Monacci WJ, Dougherty G, Cutler ML . (2002). Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas. J Neurooncol 60: 201–211.

    Article  PubMed  Google Scholar 

  • Ciampi R, Nikiforov YE . (2007). RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis. Endocrinology 148: 936–941.

    Article  CAS  PubMed  Google Scholar 

  • Collard JG, Habets GG, Michiels F, Stam J, van der Kammen RA, van Leeuwen F . (1996). Role of Tiam 1 in Rac-mediated signal transduction pathways. Curr Top Microbiol Immunol 213 (Part 2): 253–265.

    CAS  PubMed  Google Scholar 

  • Corson TW, Gallie BL . (2007). One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma. Genes Chromosomes Cancer 46: 617–634.

    Article  CAS  PubMed  Google Scholar 

  • De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M et al. (2005). RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors. Oncogene 24: 6303–6313.

    Article  CAS  PubMed  Google Scholar 

  • DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) (2004). World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of Endocrine Organs. IARC Press: Lyon.

    Google Scholar 

  • Demichelis F, Fall K, Perner S, Andren O, Schmidt F, Setlur SR et al. (2007). TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene 26: 4596–4599.

    Article  CAS  PubMed  Google Scholar 

  • Dickinson RE, Dallol A, Bieche I, Krex D, Morton D, Maher ER et al. (2004). Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers. Br J Cancer 91: 2071–2078.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Djeu JY, Jiang K, Wei S . (2002). A view to a kill: signals triggering cytotoxicity. Clin Cancer Res 8: 636–640.

    CAS  PubMed  Google Scholar 

  • Dong M, How T, Kirkbride KC, Gordon KJ, Lee JD, Hempel N et al. (2007). The type III TGF-beta receptor suppresses breast cancer progression. J Clin Invest 117: 206–217.

    Article  CAS  PubMed  Google Scholar 

  • Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W et al. (2006). ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell 21: 51–64.

    Article  CAS  PubMed  Google Scholar 

  • Duquette ML, Huber MD, Maizels N . (2007). G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas. Cancer Res 67: 2586–2594.

    Article  CAS  PubMed  Google Scholar 

  • Elisei R, Romei C, Vorontsova T, Cosci B, Veremeychik V, Kuchinskaya E et al. (2001). RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. J Clin Endocrinol Metab 86: 3211–3216.

    CAS  PubMed  Google Scholar 

  • Engers R, Mueller M, Walter A, Collard JG, Willers R, Gabbert HE . (2006). Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer 95: 1081–1086.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fiegler H, Carr P, Douglas EJ, Burford DC, Hunt S, Scott CE et al. (2003). DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer 36: 361–374.

    Article  CAS  PubMed  Google Scholar 

  • Finn SP, Smyth P, O’Regan E, Cahill S, Flavin R, O’Leary J et al. (2004). Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes. Virchows Arch 445: 396–404.

    Article  CAS  PubMed  Google Scholar 

  • Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I et al. (1990). PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60: 557–563.

    Article  CAS  PubMed  Google Scholar 

  • Hammarsund M, Corcoran MM, Wilson W, Zhu C, Einhorn S, Sangfelt O et al. (2004). Characterization of a novel B-CLL candidate gene—DLEU7—located in the 13q14 tumor suppressor locus. FEBS Lett 556: 75–80.

    Article  CAS  PubMed  Google Scholar 

  • Hou P, Liu D, Shan Y, Hu S, Studeman K, Condouris S et al. (2007). Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. Clin Cancer Res 13: 1161–1170.

    Article  CAS  PubMed  Google Scholar 

  • Hou W, Medynski D, Wu S, Lin X, Li LY . (2005). VEGI-192, a new isoform of TNFSF15, specifically eliminates tumor vascular endothelial cells and suppresses tumor growth. Clin Cancer Res 11: 5595–5602.

    Article  CAS  PubMed  Google Scholar 

  • Hu S, Liu D, Tufano RP, Carson KA, Rosenbaum E, Cohen Y et al. (2006). Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer 119: 2322–2329.

    Article  CAS  PubMed  Google Scholar 

  • Huang H, Sossey-Alaoui K, Beachy SH, Geradts J . (2007). The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. J Cancer Res Clin Oncol 133: 761–769.

    Article  CAS  PubMed  Google Scholar 

  • Hupe P, Stransky N, Thiery JP, Radvanyi F, Barillot E . (2004). Analysis of array CGH data: from signal ratio to gain and loss of DNA regions. Bioinformatics 20: 3413–3422.

    Article  CAS  PubMed  Google Scholar 

  • Ishizaka Y, Kobayashi S, Ushijima T, Hirohashi S, Sugimura T, Nagao M . (1991). Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method. Oncogene 6: 1667–1672.

    CAS  PubMed  Google Scholar 

  • Jhiang SM, Mazzaferri EL . (1994). The ret/PTC oncogene in papillary thyroid carcinoma. J Lab Clin Med 123: 331–337.

    CAS  PubMed  Google Scholar 

  • Jimenez-Velasco A, Roman-Gomez J, Agirre X, Barrios M, Navarro G, Vazquez I et al. (2005). Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia. Leukemia 19: 2347–2350.

    Article  CAS  PubMed  Google Scholar 

  • Kadota M, Tamaki Y, Sekimoto M, Fujiwara Y, Aritake N, Hasegawa S et al. (2003). Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma. Oncol Rep 10: 35–38.

    CAS  PubMed  Google Scholar 

  • Kitamura Y, Shimizu K, Nagahama M, Sugino K, Ozaki O, Mimura T et al. (1999). Immediate causes of death in thyroid carcinoma: clinicopathological analysis of 161 fatal cases. J Clin Endocrinol Metab 84: 4043–4049.

    Article  CAS  PubMed  Google Scholar 

  • Klugbauer S, Lengfelder E, Demidchik EP, Rabes HM . (1995). High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene 11: 2459–2467.

    CAS  PubMed  Google Scholar 

  • Konishi T, Sasaki S, Watanabe T, Kitayama J, Nagawa H . (2006). Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. Oncogene 25: 3160–3169.

    Article  CAS  PubMed  Google Scholar 

  • La Rosa P, Viara E, Hupe P, Pierron G, Liva S, Neuvial P et al. (2006). VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles. Bioinformatics 22: 2066–2073.

    Article  CAS  PubMed  Google Scholar 

  • Li L, Ross AH . (2007). Why is PTEN an important tumor suppressor? J Cell Biochem 102: 1368–1374.

    Article  CAS  PubMed  Google Scholar 

  • Louhelainen JP, Hurst CD, Pitt E, Nishiyama H, Pickett HA, Knowles MA . (2006). DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. Oncogene 25: 2409–2419.

    Article  CAS  PubMed  Google Scholar 

  • Nagata S . (1994). Fas and Fas ligand: a death factor and its receptor. Adv Immunol 57: 129–144.

    Article  CAS  PubMed  Google Scholar 

  • Neuvial P, Hupe P, Brito I, Liva S, Manie E, Brennetot C et al. (2006). Spatial normalization of array-CGH data. BMC Bioinformatics 7: 264.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O’Carroll D et al. (2001). Rb targets histone H3 methylation and HP1 to promoters. Nature 412: 561–565.

    Article  CAS  PubMed  Google Scholar 

  • O’Donnell KA, Yu D, Zeller KI, Kim JW, Racke F, Thomas-Tikhonenko A et al. (2006). Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis. Mol Cell Biol 26: 2373–2386.

    Article  PubMed  PubMed Central  Google Scholar 

  • Okawa ER, Gotoh T, Manne J, Igarashi J, Fujita T, Silverman KA et al. (2008). Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas. Oncogene 27: 803–810.

    Article  CAS  PubMed  Google Scholar 

  • Pierotti MA, Santoro M, Jenkins RB, Sozzi G, Bongarzone I, Grieco M et al. (1992). Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC. Proc Natl Acad Sci USA 89: 1616–1620.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Powell N, Jeremiah S, Morishita M, Dudley E, Bethel J, Bogdanova T et al. (2005). Frequency of BRAF T1796A mutation in papillary thyroid carcinoma relates to age of patient at diagnosis and not to radiation exposure. J Pathol 205: 558–564.

    Article  CAS  PubMed  Google Scholar 

  • Puxeddu E, Knauf JA, Sartor MA, Mitsutake N, Smith EP, Medvedovic M et al. (2005). RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response. Endocr Relat Cancer 12: 319–334.

    Article  CAS  PubMed  Google Scholar 

  • Rabes HM, Demidchik EP, Sidorow JD, Lengfelder E, Beimfohr C, Hoelzel D et al. (2000). Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. Clin Cancer Res 6: 1093–1103.

    CAS  PubMed  Google Scholar 

  • Repana K, Papazisis K, Foukas P, Valeri R, Kortsaris A, Deligiorgi E et al. (2006). Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness. Anticancer Res 26: 4949–4954.

    CAS  PubMed  Google Scholar 

  • Rhoden KJ, Johnson C, Brandao G, Howe JG, Smith BR, Tallini G . (2004). Real-time quantitative RT-PCR identifies distinct c-RET, RET/PTC1 and RET/PTC3 expression patterns in papillary thyroid carcinoma. Lab Invest 84: 1557–1570.

    Article  CAS  PubMed  Google Scholar 

  • Rhoden KJ, Unger K, Salvatore G, Yilmaz Y, Vovk V, Chiappetta G et al. (2006). RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma. J Clin Endocrinol Metab 91: 2414–2423.

    Article  CAS  PubMed  Google Scholar 

  • Richter H, Braselmann H, Hieber L, Thomas G, Bogdanova T, Tronko N et al. (2004). Chromosomal imbalances in post-chernobyl thyroid tumors. Thyroid 14: 1061–1064.

    Article  PubMed  Google Scholar 

  • Riedl SJ, Salvesen GS . (2007). The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 8: 405–413.

    Article  CAS  PubMed  Google Scholar 

  • Rouveirol C, Stransky N, Hupe P, Rosa PL, Viara E, Barillot E et al. (2006). Computation of recurrent minimal genomic alterations from array-CGH data. Bioinformatics 22: 849–856.

    Article  CAS  PubMed  Google Scholar 

  • Santoro M, Carlomagno F, Melillo RM, Fusco A . (2004). Dysfunction of the RET receptor in human cancer. Cell Mol Life Sci 61: 2954–2964.

    Article  CAS  PubMed  Google Scholar 

  • Shan Z, Parker T, Wiest JS . (2004). Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer. Oncogene 23: 6612–6620.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Singh B, Lim D, Cigudosa JC, Ghossein R, Shaha AR, Poluri A et al. (2000). Screening for genetic aberrations in papillary thyroid cancer by using comparative genomic hybridization. Surgery 128: 888–893; discussion 893–894.

    Article  CAS  PubMed  Google Scholar 

  • Smida J, Salassidis K, Hieber L, Zitzelsberger H, Kellerer AM, Demidchik EP et al. (1999). Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus. Int J Cancer 80: 32–38.

    Article  CAS  PubMed  Google Scholar 

  • Takakura S, Kohno T, Manda R, Okamoto A, Tanaka T, Yokota J . (2001). Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. Int J Oncol 18: 817–824.

    CAS  PubMed  Google Scholar 

  • Tan X, Wang JY . (1998). The caspase-RB connection in cell death. Trends Cell Biol 8: 116–120.

    Article  CAS  PubMed  Google Scholar 

  • Thomas GA, Bunnell H, Cook HA, Williams ED, Nerovnya A, Cherstvoy ED et al. (1999). High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. J Clin Endocrinol Metab 84: 4232–4238.

    CAS  PubMed  Google Scholar 

  • Torosyan Y, Dobi A, Naga S, Mezhevaya K, Glasman M, Norris C et al. (2006). Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription. Cancer Res 66: 9609–9616.

    Article  CAS  PubMed  Google Scholar 

  • Unger K, Zitzelsberger H, Salvatore G, Santoro M, Bogdanova T, Braselmann H et al. (2004). Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas. J Clin Endocrinol Metab 89: 4272–4279.

    Article  CAS  PubMed  Google Scholar 

  • Unger K, Zurnadzhy L, Walch A, Mall M, Bogdanova T, Braselmann H et al. (2006). RET rearrangements in post-Chernobyl papillary thyroid carcinomas with a short latency analysed by interphase FISH. Br J Cancer 94: 1472–1477.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • van Beers EH, Joosse SA, Ligtenberg MJ, Fles R, Hogervorst FB, Verhoef S et al. (2006). A multiplex PCR predictor for aCGH success of FFPE samples. Br J Cancer 94: 333–337.

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Hou P, Yu H, Wang W, Ji M, Zhao S et al. (2007). High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors. J Clin Endocrinol Metab 92: 2387–2390.

    Article  CAS  PubMed  Google Scholar 

  • Worthylake DK, Rossman KL, Sondek J . (2000). Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature 408: 682–688.

    Article  CAS  PubMed  Google Scholar 

  • Wreesmann VB, Estilo C, Eisele DW, Singh B, Wang SJ . (2007). Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec 69: 218–225.

    Article  CAS  PubMed  Google Scholar 

  • Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G et al. (2005). Tumor suppressive role of a 2.4 Mb 9q33–q34 critical region and DEC1 in esophageal squamous cell carcinoma. Oncogene 24: 697–705.

    Article  CAS  PubMed  Google Scholar 

  • Yoo NJ, Lee SH, Jeong EG . (2007). Expression of phosphorylated caspase-9 in gastric carcinomas. APMIS 115: 354–359.

    Article  CAS  PubMed  Google Scholar 

  • Zhang Q, Li J, Deavers M, Abbruzzese JL, Ho L . (2005). The subcellular localization of syntaxin 17 varies among different cell types and is altered in some malignant cells. J Histochem Cytochem 53: 1371–1382.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We acknowledge Elke Konhäuser for the skilful technical assistance and Cordelia Langford and the Wellcome Trust Sanger Institute microarray facility for supplying the 1-Mb BAC arrays. This study was supported in part by EC Grant FP6-36495 and a grant from the German Cancer Aid (project no. 108033).

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Author notes

  1. K Unger and E Malisch: These authors contributed equally to this study.

Authors and Affiliations

  1. Institut für Molekulare Strahlenbiologie, Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Germany

    K Unger, E Malisch, H Braselmann & H Zitzelsberger

  2. Department of Histopathology, Hammersmith Hospital, London, UK

    K Unger & G Thomas

  3. Institut für Pathologie, Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Germany

    A Walch

  4. Institut für Strahlenbiologie, Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH, Germany

    G Jackl

  5. Swansea Medical School, Swansea University, Singleton Park, Swansea, UK,

    P Lewis

  6. Strahlenbiologisches Institut, Ludwig Maximilians Universität, München, Germany

    E Lengfelder

  7. Institute of Endocrinology and Metabolism, Academy of Medical Sciences of the Ukraine, Kiev, Ukraine

    T Bogdanova

  8. Department Biologie II, Anthropologie und Humangenetik, Ludwig Maximilians Universität, München, Germany

    J Wienberg

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  1. K Unger
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  2. E Malisch
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Correspondence to H Zitzelsberger.

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Supplementary Information accompanies the paper on the Oncogene website (http://www.nature.com/onc).

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Unger, K., Malisch, E., Thomas, G. et al. Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC. Oncogene 27, 4592–4602 (2008). https://doi.org/10.1038/onc.2008.99

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