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High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus

Journal of Perinatology volume 38, pages 1483–1489 (2018)Cite this article

Subjects

Abstract

Objective

To investigate if a hemodynamically significant patent ductus arteriosus (hsPDA) leads to elevated high-sensitivity troponin T (hsTnT) and NTproBNP levels in serum.

Study design

Infants <34 weeks and <1500 g were prospectively enrolled, except those with major congenital or chromosomal anomalies. An echocardiogram (ECHO) was performed and hsTnT and NTproBNP were measured within 5 days of life and repeated after treatment of hsPDA. Clinical, ECHO, and hsTnT data were analyzed using Student t-test, two proportion z-test, and regression analysis.

Results

Seventy infants were enrolled. Infants in the hsPDA group had lower gestation and birth weight. Mean hsTnT and NTproBNP levels in the hsPDA group were higher compared to the group without an hsPDA, with levels being 251.54 vs 161.6 pg/ml, p < 0.01 for hsTnT and 18181.02 vs 3149.23 pg/ml, p < 0.001 for NTproBNP.

Conclusion

HsPDA leads to increased hsTnT and NTproBNP levels in preterm infants without affecting cardiac function.

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Acknowledgements

We would like to acknowledge Catharine White Creech and Lacie Dixon who did the ECHOs of all subjects recruited in the study. The study would not be possible without their help. We would also like to acknowledge all the parents who allowed us to include their infants in the study. We want to acknowledge Roche pharmaceutical (Indianapolis, IN, USA) for their support in the measurement of hsTnT levels.

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Authors and Affiliations

  1. Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA

    Priyanka Asrani, Ashraf M. Aly, Amyn K. Jiwani, Bruce R. Niebuhr & Sunil K. Jain

  2. Department of Pathology, University of Maryland Medical Center, Baltimore, MD, USA

    Robert H. Christenson

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  1. Priyanka Asrani
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Corresponding author

Correspondence to Sunil K. Jain.

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Conflict of interest

The authors declare that they have no conflict of interest. However, we have received support from Roche Diagnostics, Indianapolis, IN, USA, who provided us with the Elecsys 2010 assay for biomarker analysis for this study, but Roche Diagnostics was not involved in the analysis and interpretation of the research data.

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Asrani, P., Aly, A.M., Jiwani, A.K. et al. High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus. J Perinatol 38, 1483–1489 (2018). https://doi.org/10.1038/s41372-018-0192-x

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