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Molecular factors shaping whether HCMV infection is productive or latent

Nature Microbiology volume 8, pages 373–374 (2023)Cite this article

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Human cytomegalovirus (HCMV) has two modes of infection: productive and latent. Tracking HCMV infection with single-cell transcriptomics revealed that infection outcome (productive or latent) is based on viral gene expression levels at early stages of infection. Moreover, intrinsic levels of interferon-stimulated genes affect viral gene expression and the outcome of infection.

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Fig. 1: Single-cell transcriptomics applied to study HCMV infection.

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This is a summary of: Schwartz, M. et al. Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics. Nat. Microbiol. https://doi.org/10.1038/10.1038/s41564-023-01325-x (2023).

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Molecular factors shaping whether HCMV infection is productive or latent. Nat Microbiol 8, 373–374 (2023). https://doi.org/10.1038/s41564-023-01331-z

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