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IL-6: linking chronic inflammation and vascular calcification

Nature Reviews Rheumatology volume 15, pages 457–459 (2019)Cite this article

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New data highlight the contribution of IL-6 to vascular calcification in chronic inflammation. Given that increased vascular calcification and accelerated atherosclerosis occur in patients with chronic inflammatory diseases, new therapies that block the IL-6 pathway might reduce the risk of cardiovascular events in these patients.

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Acknowledgements

The work of M.A.G.-G is supported by grants from Fondo de Investigación Sanitaria (PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) and RETICS Programs (RD12/0009 and RD16/0012) (RIER) from the Instituto de Salud Carlos III (ISCIII, Health Ministry, Spain) and European Union FEDER funds. R.L.-M. is a recipient of the Miguel Servet type I Program fellowship supported by ISCIII, co-funded by the European Social Fund (“Investing in your future”) (CP16/00033).

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Author notes

  1. These authors contributed equally: Raquel López-Mejías and Miguel A. González-Gay.

Authors and Affiliations

  1. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, University of Cantabria, Santander, Spain

    Raquel López-Mejías & Miguel A. González-Gay

Authors
  1. Raquel López-Mejías
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  2. Miguel A. González-Gay
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Correspondence to Raquel López-Mejías or Miguel A. González-Gay.

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Competing interests

M.A.G.-G declares that he has received research support from AbbVie, MSD, Jansen and Roche, and has received consultation fees or has participated in a company-sponsored speaker´s bureau from AbbVie, Pfizer, Roche, Sanofi, Celgene, Sobi and MSD. R.L.-M. declares no competing interests.

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López-Mejías, R., González-Gay, M.A. IL-6: linking chronic inflammation and vascular calcification. Nat Rev Rheumatol 15, 457–459 (2019). https://doi.org/10.1038/s41584-019-0259-x

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