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Post-Transplant Complications

Liver disease during the first post-transplant year in bone marrow transplantation recipients: retrospective study

Bone Marrow Transplantation volume 26, pages 193–197 (2000)Cite this article

Abstract

Liver dysfunction is a common problem in BMT recipients and it is important to determine the etiology in order to institute appropriate therapy. The purpose of this study was to evaluate the possible causes of liver dysfunction during the first post-transplant year in BMT recipients and to identify a possible relationship between pre-existing liver dysfunction and viral hepatitis with prognosis after BMT. We reviewed liver status before and after BMT in 130 consecutive patients at the Catholic Hematopoietic Stem Cell Transplantation Center. Liver dysfunction during the first post-transplant year occurred in 85 out of 101 (84.2%) allogeneic BMT recipients and 13 out of 29 (44.8%) autologous BMT recipients. In allogeneic BMT, GVHD and drug hepatotoxicity were major causes. In autologous BMT, drug hepatotoxicity was the most common cause. Eighteen out of 130 patients (13.8%) had abnormal liver function tests before BMT. These patients did not have an increased risk of post-transplant liver dysfunction, GVHD, and death compared to patients who had normal liver function tests prior to BMT. Nine patients were hepatitis B antigen positive and three patients were anti-HCV positive prior to BMT. There was no significant increase in the incidence of post-transplant liver dysfunction, GVHD, and death in these patients. Bone Marrow Transplantation (2000) 26, 193–197.

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Acknowledgements

Catholic Research Institute of Medical Science Grant 1998 supported this study.

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Authors and Affiliations

  1. Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea

    BK Kim, KW Chung & HS Sun

  2. Department of Clinical Pathology, The Catholic University of Korea, Seoul, Korea

    CS Kang & SI Sim

  3. The Catholic Hemopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea

    JG Suh, WS Min, WS Shin & CC Kim

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  1. BK Kim
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Kim, B., Chung, K., Sun, H. et al. Liver disease during the first post-transplant year in bone marrow transplantation recipients: retrospective study. Bone Marrow Transplant 26, 193–197 (2000). https://doi.org/10.1038/sj.bmt.1702453

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