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Infections Post Transplant

Adenovirus infections following haematopoietic cell transplantation: is there a role for adoptive immunotherapy?

Bone Marrow Transplantation volume 26, pages 305–307 (2000)Cite this article

Abstract

Adenovirus has been recognised as an important pathogen in BMT recipients, especially in patients with GVHD and those receiving T cell-depleted allografts. We report adenovirus infections from an ongoing surveillance study in four patients after a non-myeloablative transplant and their improved outcome following withdrawal of immunosuppression in two patients and donor lymphocyte infusion for relapsed disease in the others. We discuss the control of adenovirus infections following immune manipulations and the feasibility of adoptive immunotherapy for post-transplant adenovirus infections. Bone Marrow Transplantation (2000) 26, 305–307.

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References

  1. Shields AF, Hackman RC, Fife KH et al. Adenovirus infections in patients undergoing bone marrow transplantation New Engl J Med 1985 312: 529–533

    Article  CAS  Google Scholar 

  2. Flomenberg P, Babbitt J, Drobyski WR et al. Increased incidence of adenovirus disease in bone marrow transplant recipients J Infect Dis 1994 169: 775–781

    Article  CAS  Google Scholar 

  3. Blanke C, Clark C, Broun R et al. Evolving pathogens in allogeneic bone marrow transplantation: increased fatal adenoviral infections Am J Med 1995 99: 326–328

    Article  CAS  Google Scholar 

  4. Chakrabarti S, Collingham KE, Fegan C, Milligan DW . Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy Bone Marrow Transplant 1999 23: 1209–1211

    Article  CAS  Google Scholar 

  5. Rooney CM, Smith CA, Ng CYC et al. Infusion of cytotoxic T cells for the prevention and treatment of Epstein–Barr virus-induced lymphoma in allogeneic transplant recipients Blood 1998 92: 1549–1555

    CAS  PubMed  Google Scholar 

  6. Hromas R, Cornetta K, Srour E et al. Donor leukocyte infusion as therapy of life-threatening adenoviral infections after T-cell-depleted bone marrow transplantation Blood 1994 84: 1689–1690

    CAS  PubMed  Google Scholar 

  7. Miyamoto T, Gondo H, Miyoshi Y et al. Early viral complications following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma Br J Haematol 1998 100: 348–350

    Article  CAS  Google Scholar 

  8. Childs R, Sanchez C, Engler H et al. High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine Bone Marrow Transplant 1998 22: 889–893

    Article  CAS  Google Scholar 

  9. Flomenberg P, Piaskowski V, Truitt RL, Casper JT . Characterisation of human T cell responses to adenovirus J Infect Dis 1995 171: 1090–1096

    Article  CAS  Google Scholar 

  10. Flomenberg P, Piaskowski V, Truitt RL, Casper JT . Human adenovirus specific CD8+ T-cell responses are not inhibited by E3–19K in the presence of gamma interferon J Virol 1996 70: 6314–6322

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Smith CA, Woodruff LS, Kitchingman GR, Rooney CM . Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro J Virol 1996 70: 6733–6740

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK

    S Chakrabarti, CD Fegan & DW Milligan

  2. Department of Public Health Laboratory, Birmingham Heartlands Hospital, Birmingham, UK

    KE Collingham & D Pillay

Authors
  1. S Chakrabarti
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  2. KE Collingham
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  3. CD Fegan
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  4. D Pillay
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  5. DW Milligan
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Chakrabarti, S., Collingham, K., Fegan, C. et al. Adenovirus infections following haematopoietic cell transplantation: is there a role for adoptive immunotherapy?. Bone Marrow Transplant 26, 305–307 (2000). https://doi.org/10.1038/sj.bmt.1702508

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  • DOI: https://doi.org/10.1038/sj.bmt.1702508

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