Abstract
A paediatric patient was treated with orthotopic liver transplantation after he developed cirrhosis of the liver due to chronic graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation. His pre-existing chronic GVHD of the skin disappeared and immunosuppressive therapy could be gradually tapered and finally withdrawn 71 months after liver transplantation. Two and a half years after discontinuation of all immunosuppressive therapy, the patient is in excellent condition with neither signs of chronic GVHD nor rejection of the liver graft.
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References
Urban C, Binder B, Hauer C et al. Congenital sideroblastic anemia successfully treated by allogeneic bone marrow transplantation Bone Marrow Transplant 1992 10: 373 375
Rhodes DF, Lee WM, Wingard JR et al. Orthotopic liver transplantation for graft-versus-host disease following bone marrow transplantation Gastroenterology 1990 99: 536 538
Nimer SD, Milewicz AL, Champlin RE, Busuttil RW . Successful treatment of hepatic venoocclusive disease in a bone marrow transplant patient with orthotopic liver transplantation Transplantation 1990 49: 819 821
Rapoport AP, Doyle HR, Starzl T et al. Orthotopic liver transplantation for life-threatening veno-occlusive disease of the liver after allogeneic bone marrow transplant Bone Marrow Transplant 1991 8: 421 424
Marks DI, Dousset B, Robson A et al. Orthotopic liver transplantation for hepatic GVHD following allogeneic BMT for chronic myeloid leukemia Bone Marrow Transplant 1992 10: 463 466
Schlitt HJ, Tischler HJ, Ringe B et al. Allogeneic liver transplantation for hepatic veno-occlusive disease after bone marrow transplantation – clinical and immunological considerations Bone Marrow Transplant 1995 16: 473 478
Rosen HR, Martin P, Schiller GJ et al. Orthotopic liver transplantation for bone-marrow transplant-associated veno-occlusive disease and graft-versus-host disease of the liver Liver Transpl Surg 1996 2: 225 232
Figuera A, Tomas JF, Otero MJ et al. Orthotopic liver transplantation for acute grade IV hepatic graft-versus-host disease following bone marrow transplantation Am J Hematol 1996 52: 68 69
Bunin N, Leahey A, Dunn S . Related donor liver transplant for veno-occlusive disease following T-depleted unrelated donor bone marrow transplantation Transplantation 1996 61: 664 666
Starzl TE, Demetris AJ, Murase N et al. Cell migration, chimerism, and graft acceptance Lancet 1992 339: 1579 1582
Starzl TE, Murase N . Microchimerism, macrochimerism, and tolerance Clin Transplant 2000 14: 351 354
Starzl TE, Zinkernagel RM . Antigen localization and migration in immunity and tolerance New Engl J Med 1998 339: 1905 1913
Starzl T, Demetris AJ, Trucco M et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance Hepatology 1993 17: 1127 1152
Svendsen UG, Aggestrup S, Heilmann C et al. Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow Eur Respir J 1995 8: 334 337
Helg C, Chapuis B, Bolle JF et al. Renal transplantation without immunosuppression in a host with tolerance induced by allogeneic bone marrow transplantation Transplantation 1994 58: 1420 1422
Butcher JA, Hariharan S, Adams MB et al. Renal transplantation for end-stage renal disease following bone marrow transplantation: a report of six cases, with and without immunosuppression Clin Transplant 1999 13: 330 335
Sellers MT, Deierhoi MH, Curtis JJ et al. Tolerance in renal transplantation after allogeneic bone marrow transplantation-6-year follow-up Transplantation 2001 71: 1681 1683
Mathes-Martin S, Peters C, Königsrainer A et al. Successful stem cell transplantation following orthotopic liver transplantation from the same haploidentical family donor in a girl with hemophagocytic lymphohistiocytosis Blood 2000 96: 3997 3999
Knobler HY, Sagher U, Peled IJ et al. Tolerance to donor-type skin in the recipient of a bone marrow allograft Transplantation 1985 40: 223 225
Fung JJ . Donor bone marrow augmentation in clinical organ transplantation Acta Chir Austriaca 2000 32: 8 10
Rao AS, Fontes P, Dodson F et al. Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients Transplant Proc 1996 28: 2959 2965
Mathew JM, Miller J . Immunregulatory role of chimerism in clinical organ transplantation Bone Marrow Transplantat 2001 28: 115 119
Slavin S . New strategies for bone marrow transplantation Curr Opin Immunol 2000 12(5): 542 551
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We are indebted to Prof Shimon Slavin for critically reviewing and Mrs Juliana Schmidt for excellent typing of the manuscript.
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Urban, C., Deutschmann, A., Kerbl, R. et al. Organ tolerance following cadaveric liver transplantation for chronic graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplant 30, 535–537 (2002). https://doi.org/10.1038/sj.bmt.1703688
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DOI: https://doi.org/10.1038/sj.bmt.1703688
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