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Post-Transplant Complications

TNF polymorphisms are associated with toxic but not with aGVHD complications in the recipients of allogeneic sibling haematopoietic stem cell transplantation

Bone Marrow Transplantation volume 32, pages 617–622 (2003)Cite this article

Summary:

NcoI polymorphism within the promoter/enhancer region of TNFα and the first intron of TNFβ encoding gene was analysed in 70 patients with haematological malignancies transplanted from HLA-identical sibling donors. The control group was composed of 130 healthy individuals. We showed that patients heterozygous for one or both TNF genes suffered more frequently from severe (grades III–IV) toxic complications than those carrying the other TNF genotypes (TNFA*1,2: 9/10 vs 30/60, P<0.05; TNFB*1,2: 20/26 vs 19/44, P<0.01; TNFA*1,2 TNFB*1,2: 9/9 vs 30/61, P<0.005). Conversely, patients having TNFB*2,2 less frequently presented with severe toxic lesions (17/39 vs 22/31, P<0.05). Additional analyses showed that TNFA*1,2, independent of the TNFB genotype composition, influenced the manifestation of grades III–IV toxic lesions, while TNFB*2,2 and TNFA*1,1 in combined association played a protective role. Logistic regression analysis confirmed the association of recipient TNFA*1,2 genotype with severe toxic complications, in addition to aggressive myeloablative conditioning regimen and female to male transplantation. No relation was found between TNF polymorphic features and aGvHD incidence by either uni- or multivariable analyses.

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Acknowledgements

This work has been funded by a grant from the Polish State Committee for Scientific Research (KBN; No. 6 P05B 056 20). We are grateful to Dr SBA Cohen for her help in the final preparation of the manuscript.

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Authors and Affiliations

  1. L Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

    K Bogunia-Kubik & A Lange

  2. Lower Silesian Center for Cellular Transplantation & National Polish Bone Marrow Donor Registry, Wrocław, Poland

    M Polak & A Lange

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  1. K Bogunia-Kubik
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  2. M Polak
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Correspondence to A Lange.

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Bogunia-Kubik, K., Polak, M. & Lange, A. TNF polymorphisms are associated with toxic but not with aGVHD complications in the recipients of allogeneic sibling haematopoietic stem cell transplantation. Bone Marrow Transplant 32, 617–622 (2003). https://doi.org/10.1038/sj.bmt.1704200

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