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Lectin Deficiency

Successful haemopoietic stem cell transplantation does not correct mannan-binding lectin deficiency

Bone Marrow Transplantation volume 35, pages 179–181 (2005)Cite this article

Abstract

Summary:

It has been reported that in allogeneic stem cell transplantation, the mannan-binding lectin (MBL) status of the donor has prognostic value for the recipient. Two MBL-deficient patients, with coexisting haematological malignancy, were identified who were treated with bone marrow from donors with normal MBL concentrations. Although both patients engrafted successfully and remain in complete remission, neither seroconverted to the MBL sufficiency status of his donor over a follow-up period exceeding 2 years. This does not support the concept of MBL replacement by stem cell therapy, and does not provide an explanation for high MBL concentrations in stem cell donors protecting recipients from post transplant infections.

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Authors and Affiliations

  1. SNBTS National Science Laboratory, Edinburgh, UK

    D C Kilpatrick

  2. Section of Experimental Haematology, Division of Cancer Sciences and Molecular Pathology, University of Glasgow, UK

    K Stewart, E K Allan, L A McLintock & T L Holyoake

  3. Academic Transfusion Medicine Unit, University of Edinburgh, UK

    M L Turner

Authors
  1. D C Kilpatrick
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  2. K Stewart
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  3. E K Allan
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  4. L A McLintock
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  5. T L Holyoake
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  6. M L Turner
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Correspondence to D C Kilpatrick.

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Kilpatrick, D., Stewart, K., Allan, E. et al. Successful haemopoietic stem cell transplantation does not correct mannan-binding lectin deficiency. Bone Marrow Transplant 35, 179–181 (2005). https://doi.org/10.1038/sj.bmt.1704746

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  • DOI: https://doi.org/10.1038/sj.bmt.1704746

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