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Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris

European Journal of Clinical Nutrition volume 56, pages 1039–1045 (2002)Cite this article

Abstract

Objective: To evaluate the effects of moderate weight loss, in overweight patients with angina, on plasma coagulation, fibrinolytic indicies and pain frequency.

Design: Single-stranded 12-week dietary intervention, an individualised eating plan with quantitative advice delivered by a dietitian. Target weight loss of 0.5 kg per week.

Setting: Outpatient research clinic.

Subjects: Fifty-four volunteers with angina pectoris were recruited. Five subjects withdrew, so 27 males, 22 females, mean body mass index (BMI) 29.3 (s.d. 4.3) kg/m2 and age 60.3 (s.d. 6.5) y completed the intervention.

Measurements: Body weight and frequency of anginal pain. Plasma fibrinogen, red cell aggregation (RCA), viscosity, factor VII activity, plasminogen activator inhibitor (PAI) activity, tissue plasminogen activator antigen (t-PA), plasma cholesterol, triglyceride and insulin.

Results: After the 12-week dietary intervention period, mean body weight fell by 3.5 (s.d. 2.6) kg or 4.3% (P=0.0001), range −11.7 to +1.7 kg. Mean angina frequency fell by 1.8 (s.d. 3.6) from 3.2 to 1.4 episodes/week (P=0.009) and plasma cholesterol by 0.4 (s.d. 0.7) from 6.3 to 5.9 mmol/l (P=0.0001). HDL cholesterol and triglyceride were unchanged. Of the coagulation and fibrinolytic factors, factor VII activity and RCA were significantly reduced by 5 (s.d. 20), IU/dl (P=0.04) and 1.3 (s.d. 1.3) arbitrary units (P=0.014), respectively.

Conclusions: A conventional dietetic intervention, resulting in 4% weight loss, offers the potential to reduce atherosclerotic and thrombotic risk, and to reduce pain frequency, in angina patients. Given the importance of this result in a public health context, these results indicate that this may be a fruitful area for future nutrition research.

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Author notes

  1. CR Hankey: Guarantor: CR Hankey.

  2. CR Hankey, MEJ Lean, GDO Lowe, A Rumley and M Woodward: Contributors: CRH was responsible for the clinical work and data analysis. MEJL contributed to study design and supervision. GDOL provided supervision of biological assays. AR carried out assays. MW provided statistical advice. All authors contributed to manuscript editing.

Authors and Affiliations

  1. Department of Human Nutrition, University of Glasgow, Glasgow, UK

    CR Hankey & MEJ Lean

  2. Department of Medicine, Glasgow, Royal Infirmary, University of Glasgow, Glasgow, UK

    GDO Lowe & A Rumley

  3. Institute for International Health, University of Sydney, Sydney, Australia

    M Woodward

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  1. CR Hankey
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Correspondence to CR Hankey.

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Hankey, C., Lean, M., Lowe, G. et al. Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris. Eur J Clin Nutr 56, 1039–1045 (2002). https://doi.org/10.1038/sj.ejcn.1601449

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