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Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles

Genes & Immunity volume 3, pages 56–58 (2002)Cite this article

Abstract

In most ethnic groups genetic susceptibility to rheumatoid arthritis (RA) is associated with certain HLA-DRB1 alleles encoding a similar sequence motif called the ‘shared epitope’ (SE) spanning amino acid positions 70 to 74 in the third diversity region of the outermost domain of the HLA-DRB1 molecule. We examined the association of the SE and RA in 83 Colombian women with established RA and 90 healthy controls. The group HLA-DRB1*04 was associated with RA with respect to controls (47% vs 18%, respectively. OR: 4.1, 95%CI: 2.1–8.2, P < 0.001). HLA-DRB1 alleles carrying the SE QRRAA, but not those carrying QKRAA or RRRAA, were associated with disease (OR: 3.7, 95%CI: 1.73–7.83, P = 0.0009). This association was stronger among HLA-DRB1*04 carriers (OR: 23, 95%CI: 1.3–414, P = 0.002). In our population, the SE QRRAA expressed in DRB1*04 alleles appears critical in identifying women with increased susceptibility to RA.

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Authors and Affiliations

  1. Rheumatology Unit, Corporación para Investigaciones Biológicas, Medellín, Colombia, South America

    J M Anaya, P A Correa & R D Mantilla

  2. Department of Biology, University of Antioquia, Medellin, Colombia, South America

    M Arcos-Burgos

Authors
  1. J M Anaya
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  2. P A Correa
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  3. R D Mantilla
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  4. M Arcos-Burgos
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Correspondence to J M Anaya.

Additional information

This study was supported by CIB and Susalud EPS, Medellin.

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Anaya, J., Correa, P., Mantilla, R. et al. Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles. Genes Immun 3, 56–58 (2002). https://doi.org/10.1038/sj.gene.6363833

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  • DOI: https://doi.org/10.1038/sj.gene.6363833

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