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Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences

Gene Therapy volume 10, pages 946–954 (2003)Cite this article

It has been repeatedly shown – first by Shirai (1921) and Murphy (1926), and most recently by Tansley (1946) – that foreign homologous tissues grafted to the brain either do not provoke an immunity reaction or, if they do, do not respond to it. It will be shown here that they do respond to an immune state of proved effectiveness called forth by a preliminary grafting of foreign tissue elsewhere. The two questions, relating as they do to quite distinct immunological properties, may thus have contrary answers. (taken from the introduction)

Skin homografts transplanted to the brains of specifically immunized rabbits respond by total breakdown to an immune state already in being. On the testimony of other workers, they enjoy prolonged or indefinite survival when grafted to the brains of non-immunized animals.

It is concluded that skin homografts transplanted to the brain submit to but cannot elicit an immune state. (taken from the final summary)

It has been repeatedly shown – first by Shirai (1921) and Murphy (1926), and most recently by Tansley (1946) – that foreign homologous tissues grafted to the brain either do not provoke an immunity reaction or, if they do, do not respond to it. It will be shown here that they do respond to an immune state of proved effectiveness called forth by a preliminary grafting of foreign tissue elsewhere. The two questions, relating as they do to quite distinct immunological properties, may thus have contrary answers. (taken from the introduction)

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Acknowledgements

We would like to thank the Board of Governors at Cedars-Sinai Medical Center for their vision and very generous creation and funding of the GTRI. We would also like to thank Dr. Shlomo Melmed for his strong support of our program, Ms. Cheryl Cathcart for her first class administrative support, Mr. Danny Malaniak for his enthusiasm in dealing with the creation of a new place, Mrs. Semone Muslar for her excellent secretarial skills, and Mr. Nelson Jovel for the skillful and top quality editing and preparation of the figures and manuscript for publication. Work in the GTRI is funded by the NIH grants 1 RO1 NS42893 01 (to PRL), 1 RO1 NS44556 01 (to MGC) and U54 4 NS04-5309 (to PRL).

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  1. Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    P R Lowenstein & M G Castro

  2. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

    P R Lowenstein & M G Castro

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Lowenstein, P., Castro, M. Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences. Gene Ther 10, 946–954 (2003). https://doi.org/10.1038/sj.gt.3302048

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