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Circulating endothelial progenitor cells in subjects with erectile dysfunction

International Journal of Impotence Research volume 17, pages 288–290 (2005)Cite this article

Abstract

Erectile dysfunction (ED) is often the first clinical sign of endothelial dysfunction and may precede overt cardiovascular diseases. Bone marrow-derived endothelial progenitor cells migrate into the peripheral circulation to promote endothelial repair. The number of circulating progenitor cells is reduced in patients with cardiovascular risk factor. The objective of our study was to determine the number of these cells in patients with ED both with and without cardiovascular risk factors. These subjects have lower number of circulating progenitor cells, confirming the existence of an endothelial dysfunction and supplying the evidence that ED may be the first symptom of an endothelial damage.

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References

  1. Dimmeler S, Zeiher AM . Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J Mol Med 2004; 82: 671–677.

    Article  Google Scholar 

  2. Asahara T et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964–967.

    Article  CAS  Google Scholar 

  3. Aicher A, Heeschen C, Dimmeler S . The role of NOS3 in stem cell mobilization. Trends Mol Med 2004; 10: 421–425.

    Article  CAS  Google Scholar 

  4. Aicher A et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 1370–1376.

    Article  CAS  Google Scholar 

  5. Levine L, Lentig EL . Use of nocturnal penile tumescence and rigidity in the evaluation of male erectile dysfunction. Urol Clin North Am 1995; 22: 775–788.

    CAS  PubMed  Google Scholar 

  6. Scheubel RJ et al. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol 2003; 42: 2073–2080.

    Article  Google Scholar 

  7. Solomon H, Man JW, Jackson G . Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251–253.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy

    C Foresta, N Caretta, A Lana & A Ferlin

  2. Department of Clinical and Experimental Medicine, Clinical Immunology, University of Padova, Padova, Italy

    A Cabrelle

  3. Department of Histology, Microbiology, and Medical Biotechnologies, Section of Microbiology and Virology, University of Padova, Padova, Italy

    G Palù

Authors
  1. C Foresta
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  2. N Caretta
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  3. A Lana
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  4. A Cabrelle
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  5. G Palù
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  6. A Ferlin
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Correspondence to C Foresta.

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Foresta, C., Caretta, N., Lana, A. et al. Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res 17, 288–290 (2005). https://doi.org/10.1038/sj.ijir.3901311

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  • DOI: https://doi.org/10.1038/sj.ijir.3901311

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