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G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent

Leukemia volume 20, pages 1307–1310 (2006)Cite this article

Acute myeloid leukemia (AML) with MLL gene rearrangements (MLLmut) is often associated with M5 or M4 FAB subtypes, is frequent in infants and in patients with secondary leukemia following treatment with DNA topoisomerase-II inhibitors.1 MLLmut are predictive of a poor clinical outcome in AML, even if the outcome of patients with t(9;11) is more favorable than that with other MLLmut. The MLL gene (11q23) is involved in about 60 different translocations and about 30 partner genes have been identified. The most common translocation in AML is t(9;11)(p22;q23) giving rise to MLL-AF9.1

The HDAC inhibitor (HDACi) valproic acid (VPA) induces tumor-selective apoptosis through activation of the death receptor pathway AML with PML-RAR-alpha or AML1-ETO.2

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Acknowledgements

This work was supported by grants from AIRC (to AP and regional grant), MURST/FISR, and by the University of Bologna. RS, RF and MF were supported by AGEOP.

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Authors and Affiliations

  1. Department of Pediatrics, University of Bologna, Bologna, Italy

    R Tonelli, R Sartini, R Fronza, F Freccero, M Franzoni & A Pession

  2. Department of Physics, University of Bologna, Bologna, Italy

    D Dongiovanni & R Campanini

  3. Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

    M Ballarini & S Minucci

  4. Division of Medical Genetics, S. Orsola Hospital, Bologna, Italy

    S Ferrari

  5. Servizio di Genetica Medica, IRCCS-Ospedale CSS, San Giovanni Rotondo, Italy

    M D'apolito

  6. Biotech Biotechnologies Laboratory s.r.l., Parma, Italy

    G Di Cola

  7. Department of Biochemistry, University of Bologna, Bologna, Italy

    G Capranico & A Khobta

  8. Department of Pediatrics, University of Modena, Modena, Italy

    P Paolucci

  9. Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy

    S Minucci

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Correspondence to A Pession.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Tonelli, R., Sartini, R., Fronza, R. et al. G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent. Leukemia 20, 1307–1310 (2006). https://doi.org/10.1038/sj.leu.2404221

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