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Schizophrenia, neurodevelopment and corpus callosum

Molecular Psychiatry volume 8, pages 261–274 (2003)Cite this article

Abstract

The Zeitgeist favors an interpretation of schizophrenia as a condition of abnormal connectivity of cortical neurons, particularly in the prefrontal and temporal cortex. The available evidence points to reduced connectivity, a possible consequence of excessive synaptic pruning in development. A decreased thalamic input to the cerebral cortex appears likely, and developmental studies predict that this decrease should entail a secondary loss of both long- and short-range cortico-cortical connections, including connections between the hemispheres. Indeed, morphological, electrophysiological and neuropsychological studies over the last two decades suggest that the callosal connections are altered in schizophrenics. However, the alterations are subtle and sometimes inconsistent across studies, and need to be investigated further with new methodologies.

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Acknowledgements

This work was supported by Swedish Medical Research Council grant no. 12954. We are grateful to Carl Holmgren for providing useful advice on this text.

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Authors and Affiliations

  1. Division of Neuroanatomy and Brain Development, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    G M Innocenti

  2. SUPEA, Unité de Pedopsychiatrie de liaison, Hôpital Nestlé, Lausanne-CHUV, Switzerland

    G M Innocenti & F Ansermet

  3. Copenhagen University Department of Psychiatry, Cognitive Research Unit, Hvidovre Hospital, Brøndby, Denmark

    J Parnas

  4. The National Research Foundation: Center for Subjectivity Research, University of Copenhagen, Copenhagen, Denmark

    J Parnas

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  1. G M Innocenti
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Innocenti, G., Ansermet, F. & Parnas, J. Schizophrenia, neurodevelopment and corpus callosum. Mol Psychiatry 8, 261–274 (2003). https://doi.org/10.1038/sj.mp.4001205

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