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  • Review Article
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Review Article

Angiogenesis and G-protein-coupled receptors: signals that bridge the gap

Oncogene volume 20, pages 1556–1562 (2001)Cite this article

Abstract

Angiogenesis is a mechanism that has repercussions in a number of physiological and pathological situations. Vascular endothelial growth factor and basic fibroblast growth factor have understandably received enormous research coverage for being the major mediators of new blood vessel growth, often overshadowing other agonist that also have strong angiogenic potential. We wish to put the spotlight on GPCR agonists that undoubtedly have their word to say on the subject of angiogenesis. In this short review, we will discuss our findings along with the work from other groups on the mechanisms by which GPCR agonists, like thrombin and angiotensin II, control a number of angiogenic signals. A complete understanding of these mechanisms could, by the design of new therapeutic strategies, have a strong impact in clinical oncology.

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Abbreviations

Ang II:

Angiotensin II

GPCR:

G-protein coupled receptor

HIF:

Hypoxia Inducible Factor

HUVEC:

Human Umbilical Vein Endothelial Cells

ROS:

Reactive Oxygen Species

VEGF:

Vascular Endothelial Growth Factor

pVHL:

von Hippel-Lindau protein complex

VSMC:

Vascular Smooth Muscle Cells.

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Acknowledgements

The authors wish to thank Dr Edurne Berra for her critical reading of the manuscript. DE Richard is a recipient of a Fellowship from the Canadian Institutes of Health Research (CIHR). This work was supported by grants from the Centre National de la Recherche Scientifique (CNRS), the University of Nice, La Ligue Nationale Contre le Cancer (Equipe labellisée), and the GIP HMR contract.

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  1. Institute of Signaling, Developmental Biology and Cancer Research, UMR-CNRS 6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189, Nice, France

    Darren E Richard, Valérie Vouret-Craviari & Jacques Pouysségur

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Richard, D., Vouret-Craviari, V. & Pouysségur, J. Angiogenesis and G-protein-coupled receptors: signals that bridge the gap. Oncogene 20, 1556–1562 (2001). https://doi.org/10.1038/sj.onc.1204193

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