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Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients

Oncogene volume 23, pages 605–611 (2004)Cite this article

Abstract

PCGEM1 is a novel, highly prostate tissue-specific, androgen-regulated gene. Here, we demonstrate that PCGEM1 expression is significantly higher in prostate cancer (CaP) cells of African-American men than in Caucasian-American men (P=0.0002). Further, increased PCGEM1 expression associates with normal prostate epithelial cells of CaP patients with a family history of CaP (P=0.0400). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation. Taken together, the cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups.

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Abbreviations

CaP:

prostate cancer

PSA:

prostate-specific antigen

FBS:

fetal bovine serum

LCM:

laser capture microdissection

RT:

reverse transcription

H&E:

hematoxylin–eosin

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Acknowledgements

We thank Dr. Gregory Buzard for critically reading this manuscript. This research was supported by Grant #1RO1CA85596-01 from the National Institutes of Health to SS. The opinions and assertions contained herein are the private views of the authors and are not to be considered as reflecting the views of the US Army or the Department of Defense.

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Authors and Affiliations

  1. Department of Surgery, Center for Prostate Disease Research (CPDR), US Military Cancer Institute, Uniformed Services University of the Health Sciences, Bethesda, 20814-4799, MD, USA

    Gyorgy Petrovics, Mazen Makarem, Jesse P Street, Roger Connelly, Leon Sun, Vasantha Srikantan, Judd W Moul & Shiv Srivastava

  2. Department of Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, 20306-6000, DC, USA

    Wei Zhang & Isabell A Sesterhenn

  3. Urology Service, Walter Reed Army Medical Center, Washington, 20307-5001, DC, USA

    Judd W Moul

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  1. Gyorgy Petrovics
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  2. Wei Zhang
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Correspondence to Gyorgy Petrovics.

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Petrovics, G., Zhang, W., Makarem, M. et al. Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Oncogene 23, 605–611 (2004). https://doi.org/10.1038/sj.onc.1207069

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