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p300/CBP and cancer

Oncogene volume 23, pages 4225–4231 (2004)Cite this article

Abstract

p300 and cyclic AMP response element-binding protein (CBP) are adenoviral E1A-binding proteins involved in multiple cellular processes, and function as transcriptional co-factors and histone acetyltransferases. Germline mutation of CBP results in Rubinstein–Taybi syndrome, which is characterized by an increased predisposition to childhood malignancies. Furthermore, somatic mutations of p300 and CBP occur in a number of malignancies. Chromosome translocations target CBP and, less commonly, p300 in acute myeloid leukemia and treatment-related hematological disorders. p300 mutations in solid tumors result in truncated p300 protein products or amino-acid substitutions in critical protein domains, and these are often associated with inactivation of the second allele. A mouse model confirms that p300 and CBP function as suppressors of hematological tumor formation. The involvement of these proteins in critical tumorigenic pathways (including TGF-β, p53 and Rb) provides a mechanistic route as to how their inactivation could result in cancer.

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References

  • Ait-Si-Ali S, Polesskaya A, Filleur S, Ferreira R, Duquet A, Robin P, Vervish A, Trouche D, Cabon F and Harel-Bellan A . (2000). Oncogene, 19, 2430–2437.

  • Allfrey V, Faulkner R and Mirsky A . (1964). Proc. Natl. Acad. Sci. USA, 51, 786–794.

  • Allione F, Eisinger F, Parc P, Noguchi T, Sobol H and Birnbaum D . (1998). Int. J. Cancer, 75, 181–186.

  • Avantaggiati ML, Ogryzko V, Gardner K, Giordano A, Levine AS and Kelly K . (1997). Cell, 89, 1175–1184.

  • Bandyopadhyay D, Okan NA, Bales E, Nascimento L, Cole PA and Medrano EE . (2002). Cancer Res., 62, 6231–6239.

  • Bannister AJ and Kouzarides T . (1995). EMBO J., 14, 4758–4762.

  • Bannister AJ and Kouzarides T . (1996). Nature, 384, 641–643.

  • Bannister AJ, Miska EA, Gorlich D and Kouzarides T . (2000). Curr. Biol., 10, 467–470.

  • Bannister AJ, Oehler T, Wilhelm D, Angel P and Kouzarides T . (1995). Oncogene, 11, 2509–2514.

  • Barlev NA, Liu L, Chehab NH, Mansfield K, Harris KG, Halazonetis TD and Berger SL . (2001). Mol. Cell, 8, 1243–1254.

  • Borrow J, Stanton Jr VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dube I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE and Housman DE . (1996). Nat. Genet., 14, 33–41.

  • Boyes J, Byfield P, Nakatani Y and Ogryzko V . (1998). Nature, 396, 594–598.

  • Bryan EJ, Jokubaitis VJ, Chamberlain NL, Baxter SW, Dawson E, Choong DY and Campbell IG . (2002). Int. J. Cancer, 102, 137–141.

  • Bryan EJ, Watson RH, Davis M, Hitchcock A, Foulkes WD and Campbell IG . (1996). Cancer Res., 56, 719–721.

  • Cao D and Parker R . (2003). Cell, 113, 533–545.

  • Chaffanet M, Gressin L, Preudhomme C, Soenen-Cornu V, Birnbaum D and Pebusque MJ . (2000). Genes Chromosomes Cancer, 28, 138–144.

  • Champagne N, Pelletier N and Yang XJ . (2001). Oncogene, 20, 404–409.

  • Chan HM, Krstic-Demonacos M, Smith L, Demonacos C and La Thangue NB . (2001). Nat. Cell Biol., 3, 667–674.

  • Chan HM and La Thangue NB . (2001). J. Cell Sci., 114, 2363–2373.

  • Chen LC, Kurisu W, Ljung BM, Goldman ES, Moore II D and Smith HS . (1992). J. Natl. Cancer Inst., 84, 506–510.

  • Costanzo A, Merlo P, Pediconi N, Fulco M, Sartorelli V, Cole PA, Fontemaggi G, Fanciulli M, Schiltz L, Blandino G, Balsano C and Levrero M . (2002). Mol. Cell, 9, 175–186.

  • Dornan D, Shimizu H, Perkins ND and Hupp TR . (2003). J. Biol. Chem., 278, 13431–13441.

  • Duriez C, Schmitz A, Fouchet P, Buecher B, Thuille B, Lerebours F, Leger R, Boman F, Flejou JF, Monges G, Paraf F, Bedossa P, Sabourin JC, Salmon RJ, Laurent-Puig P, Thomas G and Olschwang S . (1997). Gastroenterol. Clin. Biol., 21, 358–364.

  • Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB and Livingston DM . (1994). Genes Dev., 8, 869–884.

  • Eckner R, Ludlow JW, Lill NL, Oldread E, Arany Z, Modjtahedi N, DeCaprio JA, Livingston DM and Morgan JA . (1996). Mol. Cell. Biol., 16, 3454–3464.

  • Englefield P, Foulkes WD and Campbell IG . (1994). Br. J. Cancer, 70, 905–907.

  • Espinosa JM and Emerson BM . (2001). Mol. Cell, 8, 57–69.

  • Gayther SA, Batley SJ, Linger L, Bannister A, Thorpe K, Chin SF, Daigo Y, Russell P, Wilson A, Sowter HM, Delhanty JD, Ponder BA, Kouzarides T and Caldas C . (2000). Nat. Genet., 24, 300–303.

  • Ghosh AK, Yuan W, Mori Y and Varga J . (2000). Oncogene, 19, 3546–3555.

  • Giles RH, Dauwerse JG, Higgins C, Petrij F, Wessels JW, Beverstock GC, Dohner H, Jotterand-Bellomo M, Falkenburg JH, Slater RM, van Ommen GJ, Hagemeijer A, van der Reijden BA and Breuning MH . (1997a). Leukemia, 11, 2087–2096.

  • Giles RH, Peters DJ and Breuning MH . (1998). Trends Genet., 14, 178–183.

  • Giles RH, Petrij F, Dauwerse HG, den Hollander AI, Lushnikova T, van Ommen GJ, Goodman RH, Deaven LL, Doggett NA, Peters DJ and Breuning MH . (1997b). Genomics, 42, 96–114.

  • Giordano A and Avantaggiati ML . (1999). J. Cell. Physiol., 181, 218–230.

  • Goodman RH and Smolik S . (2000). Genes Dev., 14, 1553–1577.

  • Grossman SR . (2001). Eur. J. Biochem., 268, 2773–2778.

  • Grossman SR, Deato ME, Brignone C, Chan HM, Kung AL, Tagami H, Nakatani Y and Livingston DM . (2003). Science, 300, 342–344.

  • Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM and Livingston DM . (1998). Mol. Cell, 2, 405–415.

  • Gu W and Roeder RG . (1997). Cell, 90, 595–606.

  • Ida K, Kitabayashi I, Taki T, Taniwaki M, Noro K, Yamamoto M, Ohki M and Hayashi Y . (1997). Blood, 90, 4699–4704.

  • Ito Y and Miyazono K . (2003). Curr. Opin. Genet. Dev., 13, 43–47.

  • Kawai H, Nie L, Wiederschain D and Yuan ZM . (2001). J. Biol. Chem., 276, 45928–45932.

  • Kitabayashi I, Aikawa Y, Nguyen LA, Yokoyama A and Ohki M . (2001a). EMBO J., 20, 7184–7196.

  • Kitabayashi I, Aikawa Y, Yokoyama A, Hosoda F, Nagai M, Kakazu N, Abe T and Ohki M . (2001b). Leukemia, 15, 89–94.

  • Kouzarides T . (2000). EMBO J., 19, 1176–1179.

  • Kung AL, Rebel VI, Bronson RT, Ch'ng LE, Sieff CA, Livingston DM and Yao TP . (2000). Genes Dev., 14, 272–277.

  • Lai JL, Jouet JP, Bauters F and Deminatti M . (1985). Cancer Genet. Cytogenet., 17, 365–366.

  • Lill NL, Grossman SR, Ginsberg D, DeCaprio J and Livingston DM . (1997). Nature, 387, 823–827.

  • Lipinski KS, Fax P, Wilker B, Hennemann H, Brockmann D and Esche H . (1999). Virology, 255, 94–105.

  • Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A and Kouzarides T . (2000). EMBO J., 19, 662–671.

  • Marzio G, Wagener C, Gutierrez MI, Cartwright P, Helin K and Giacca M . (2000). J. Biol. Chem., 275, 10887–10892.

  • Merika M, Williams AJ, Chen G, Collins T and Thanos D . (1998). Mol. Cell, 1, 277–287.

  • Miller RW and Rubinstein JH . (1995). Am. J. Med. Genet., 56, 112–115.

  • Miyakawa A, Wang XL, Nakanishi H, Imai FL, Shiiba M, Miya T, Imai Y and Tanzawa H . (1998). Int. J. Oncol., 13, 705–709.

  • Munshi N, Merika M, Yie J, Senger K, Chen G and Thanos D . (1998). Mol. Cell, 2, 457–467.

  • Muraoka M, Konishi M, Kikuchi-Yanoshita R, Tanaka K, Shitara N, Chong JM, Iwama T and Miyaki M . (1996). Oncogene, 12, 1565–1569.

  • Nishimori H, Nishikawa R, Fujimaki T, Nakagomi T, Matsutani M, Huang HJ and Cavenee WK . (2000). J. Neurooncol., 46, 17–22.

  • Ogryzko VV, Schiltz RL, Russanova V, Howard BH and Nakatani Y . (1996). Cell, 87, 953–959.

  • Ohshima T, Suganuma T. and Ikeda M . (2001). Biochem. Biophys. Res. Commun., 281, 569–575.

  • Oike Y, Hata A, Mamiya T, Kaname T, Noda Y, Suzuki M, Yasue H, Nabeshima T, Araki K and Yamamura K . (1999a). Hum. Mol. Genet., 8, 387–396.

  • Oike Y, Takakura N, Hata A, Kaname T, Akizuki M, Yamaguchi Y, Yasue H, Araki K, Yamamura K and Suda T . (1999b). Blood, 93, 2771–2779.

  • Ozdag H, Batley SJ, Forsti A, Iyer NG, Daigo Y, Boutell J, Arends MJ, Ponder BA, Kouzarides T and Caldas C . (2002). Br. J. Cancer, 87, 1162–1165.

  • Panagopoulos I, Fioretos T, Isaksson M, Samuelsson U, Billstrom R, Strombeck B, Mitelman F and Johansson B . (2001). Hum. Mol. Genet., 10, 395–404.

  • Pao GM, Janknecht R, Ruffner H Hunter T and Verma IM . (2000). Proc. Natl. Acad. Sci. USA, 97, 1020–1025.

  • Patel D, Huang SM, Baglia LA and McCance DJ . (1999). EMBO J., 18, 5061–5072.

  • Petrij F, Dauwerse HG, Blough RI, Giles RH, van der Smagt JJ, Wallerstein R, Maaswinkel-Mooy PD, van Karnebeek CD, van Ommen GJ, van Haeringen A, Rubinstein JH, Saal HM, Hennekam RC, Peters DJ and Breuning MH . (2000). J. Med. Genet., 37, 168–176.

  • Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ and Breuning MH . (1995). Nature, 376, 348–351.

  • Polesskaya A and Harel-Bellan A . (2001). J. Biol. Chem., 276, 44502–44503.

  • Pouponnot C, Jayaraman L and Massague J . (1998). J. Biol. Chem., 273, 22865–22868.

  • Rebel VI, Kung AL, Tanner EA, Yang H, Bronson RT and Livingston DM . (2002). Proc. Natl. Acad. Sci. USA, 99, 14789–14794.

  • Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Cantu ES, Schlegelberger B, Behm F, Doggett NA, Borrow J and Zeleznik-Le N . (1997). Blood, 90, 535–541.

  • Rubinstein JH . (1990). Am. J. Med. Genet. Suppl., 6, 3–16.

  • Ruttledge MH, Xie YG, Han FY, Peyrard M, Collins VP, Nordenskjold M and Dumanski JP . (1994). Genes Chromosomes Cancer, 10, 122–130.

  • Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW and Appella E . (1998). Genes Dev., 12, 2831–2841.

  • Satake N, Ishida Y, Otoh Y, Hinohara S, Kobayashi H, Sakashita A, Maseki N and Kaneko Y . (1997). Genes Chromosomes Cancer, 20, 60–63.

  • Shin E, Fujita S, Takami K, Kurahashi H, Kurita Y, Kobayashi T, Mori T, Nishisho I and Takai S . (1993). Jpn. J. Cancer Res., 84, 402–408.

  • Smits PH, de Wit L, van der Eb AJ and Zantema A . (1996). Oncogene, 12, 1529–1535.

  • Sobulo OM, Borrow J, Tomek R, Reshmi S, Harden A, Schlegelberger B, Housman D, Doggett NA, Rowley JD and Zeleznik-Le NJ . (1997). Proc. Natl. Acad. Sci. USA, 94, 8732–8737.

  • Strahl BD and Allis CD . (2000). Nature, 403, 41–45.

  • Suganuma T, Kawabata M, Ohshima T and Ikeda MA . (2002). Proc. Natl. Acad. Sci. USA, 99, 13073–13078.

  • Takahashi K, Kudo J, Ishibashi H, Hirata Y and Niho Y . (1993). Hepatology, 17, 794–799.

  • Takemura R, Okabe S, Umeyama T, Kanai Y, Cowan NJ and Hirokawa N . (1992). J. Cell Sci., 103 (Part 4), 953–964.

  • Taki T, Sako M, Tsuchida M and Hayashi Y . (1997). Blood, 89, 3945–3950.

  • Tillinghast GW, Partee J, Albert P, Kelley JM, Burtow KH and Kelly K . (2003). Genes Chromosomes Cancer, 37, 121–131.

  • Tomita A, Towatari M, Tsuzuki S, Hayakawa F, Kosugi H, Tamai K, Miyazaki T, Kinoshita T and Saito H . (2000). Oncogene, 19, 444–451.

  • Twist EC, Ruttledge MH, Rousseau M, Sanson M, Papi L, Merel P, Delattre O, Thomas G and Rouleau GA . (1994). Hum. Mol. Genet., 3, 147–151.

  • Yang XJ, Ogryzko VV, Nishikawa J, Howard BH and Nakatani Y . (1996). Nature, 382, 319–324.

  • Yao TP, Oh SP, Fuchs M, Zhou ND, Ch'ng LE, Newsome D, Bronson RT, Li E, Livingston DM and Eckner R . (1998). Cell, 93, 361–372.

  • Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Shi Y, Weichselbaum R and Kufe D . (1999a). Oncogene, 18, 5714–5717.

  • Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum R, Shi Y and Kufe D . (1999b). J. Biol. Chem., 274, 1883–1886.

  • Zimmermann H, Degenkolbe R, Bernard HU and O'Connor MJ . (1999). J. Virol., 73, 6209–6219.

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Acknowledgements

NGI was a recipient of the NMRC (Singapore) Medical Research Fellowship. HO was funded by a European Union Grant. Work in the Caldas laboratory is supported by Cancer Research UK.

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  1. Department of Oncology, Cancer Genomics Program, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, CB2 2XZ, UK

    Narayanan Gopalakrishna Iyer, Hilal Özdag & Carlos Caldas

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  1. Narayanan Gopalakrishna Iyer
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Correspondence to Carlos Caldas.

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Iyer, N., Özdag, H. & Caldas, C. p300/CBP and cancer. Oncogene 23, 4225–4231 (2004). https://doi.org/10.1038/sj.onc.1207118

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