Issue 1, 2012
From the journal:

Food & Function

Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

Seyed Fazel Nabavi,a   Seyed Mohammad Nabavi,*b   Akbar Hajizadeh Moghaddam,c   Alireza Naqinezhad,c   Rata Bigdellouc  and  Sakineh Mohammadzadehc  

* Corresponding authors

a National elites foundation of Iran, Tehran, Iran

b Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-546, Tehran, Iran
E-mail: Nabavi208@gmail.com
Fax: +98 21 22823734
Tel: +98 21 22823734

c Department of Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran

Abstract

Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg−1 day−1 offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg−1 day−1 has better activity than aerial parts.

Graphical abstract: Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

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Article information

DOI
https://doi.org/10.1039/C1FO10173K
Article type
Communication
Submitted
22 Aug 2011
Accepted
15 Oct 2011
First published
28 Oct 2011

Food Funct., 2012,3, 28-29

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Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

S. F. Nabavi, S. M. Nabavi, A. H. Moghaddam, A. Naqinezhad, R. Bigdellou and S. Mohammadzadeh, Food Funct., 2012, 3, 28 DOI: 10.1039/C1FO10173K

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