Issue 24, 2003
From the journal:

Organic & Biomolecular Chemistry

Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine

Keith Jones,†*a   Xavier Roset,a   Sharon Rossitera  and  Philip Whitfieldb  

* Corresponding authors

a Department of Chemistry, King's College London, Strand, UK

b School of Life Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford St, London, UK

Abstract

The synthesis of the quinoline alkaloid atanine 6, by selective demethylation of the 2,4-dimethoxyquinoline 11 is presented. An alternative demethylation utilising a thiolate anion leads to the regioisomeric 4-hydroxyquinoline 13.

Graphical abstract: Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine

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Article information

DOI
https://doi.org/10.1039/B311281K
Article type
Paper
Submitted
17 Sep 2003
Accepted
20 Oct 2003
First published
06 Nov 2003

Org. Biomol. Chem., 2003,1, 4380-4383

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Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine

K. Jones, X. Roset, S. Rossiter and P. Whitfield, Org. Biomol. Chem., 2003, 1, 4380 DOI: 10.1039/B311281K

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